1048997-21-2Relevant academic research and scientific papers
DERIVATIVES OF ADENINE AND 8-AZA-ADENINE AND USES THEREOF-796
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Page/Page column 94; 98-99, (2009/04/25)
The invention relates to chemical compounds, or pharmaceutically acceptable salts thereof of the formula (I): which have bacterial MurI inhibitory activity and are accordingly useful for their treatment and prophylaxis of bacterial infection, e.g., E.faecalis or E. faeciuminfection. Further, the invention relates to methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of the compounds, to pharmaceutical compositions containing them, and to their use in the manufacture of medicaments of use in the treatment and prevention of various bacterial diseases in a warm-blooded animalsuch as man.
Exploring 9-benzyl purines as inhibitors of glutamate racemase (MurI) in Gram-positive bacteria
Geng, Bolin,Breault, Gloria,Comita-Prevoir, Janelle,Petrichko, Randy,Eyermann, Charles,Lundqvist, Tomas,Doig, Peter,Gorseth, Elise,Noonan, Brian
scheme or table, p. 4368 - 4372 (2009/04/06)
An early SAR study of a screening hit series has generated a series of 9-benzyl purines as inhibitors of bacterial glutamate racemase (MurI) with micromolar enzyme potency and improved physical properties. X-ray co-crystal EI structures were obtained.
