229346-88-7Relevant academic research and scientific papers
Synthesis and biological activity of 9-(2,6-difluorobenzyl)-9H-purines bearing chlorine
Kozai, Shigetada,Maruyama, Tokumi
, p. 574 - 575 (1999)
Mitsunobu reaction of 2,6-dichloropurine with 2,6-difluorobenzyl alcohol gave 2,6-dichloro-9-(2,6-difluorobenzyl)-9H-purine and 7-benzylated congener in 73% and 10% yield, respectively. Treatment of the former compound with ammonia gave 2-chloro-9-(2,6-di
DERIVATIVES OF ADENINE AND 8-AZA-ADENINE AND USES THEREOF-796
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Page/Page column 59-60, (2009/04/25)
The invention relates to chemical compounds, or pharmaceutically acceptable salts thereof of the formula (I): which have bacterial MurI inhibitory activity and are accordingly useful for their treatment and prophylaxis of bacterial infection, e.g., E.faecalis or E. faeciuminfection. Further, the invention relates to methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of the compounds, to pharmaceutical compositions containing them, and to their use in the manufacture of medicaments of use in the treatment and prevention of various bacterial diseases in a warm-blooded animalsuch as man.
