104902-94-5

Basic information

• Product Name: 1H-Indole, 2,3-dihydro-1-(1-oxo-2-propenyl)-
• Synonyms: 1-(2-propenoyl)indoline
• CAS NO: 104902-94-5
• Molecular Formula: C11H11NO
• Molecular Weight: 173.21100
• Mol File: 104902-94-5.mol
• Article Data: 9

Chemical Properties

• Melting Point: 74-76°C
• CAS DataBase Reference: 1H-Indole, 2,3-dihydro-1-(1-oxo-2-propenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole, 2,3-dihydro-1-(1-oxo-2-propenyl)-(104902-94-5)
• EPA Substance Registry System: 1H-Indole, 2,3-dihydro-1-(1-oxo-2-propenyl)-(104902-94-5)

Safety Data

• Hazardous Substances Data: 104902-94-5(Hazardous Substances Data)

Usage

Uses

1-(2,3-Dihydro-1H-indol-1-yl)prop-2-en-1-one is a useful compound for the preparation of acrylamide-functionalized indolines and indoles as MTORC1 modulators for treatment of cancer, neurodegenerative and metabolic diseases.

Upstream product

• 496-15-1 1-indoline 
• 814-68-6 acryloyl chloride 

Downstream Products

• 314284-69-0 1-(indolin-1-yl)-3-phenylpropan-1-one 
• 1353779-72-2 C₃₃H₄₁NO₃Si 

Relevant articles and documents

Total synthesis of (±)-mersicarpine

(Chemical Equation Presented) The first total synthesis of the indole alkaloid mersicarpine is reported. Key steps include a β-dicarbonyl radical cyclization, as well as an oxidation of the benzopyrrole moiety to establish the masked 1,2-dicarbonyl functionality. An X-ray crystal structure and discussion of the 1H NMR behavior of the natural product are also presented.

mTORC1 MODULATORS

Provided herein, inter alia, are methods and compounds for inhibiting mTORC1 and for treating diseases associated with mTORC1 activity.

COMPOSITIONS AND METHODS FOR INHIBITING RETICULON 4

Disclosed herein, inter alia, are compositions and methods useful for inhibiting reticulon 4(RTN4).