104916-41-8

Usage

Uses

Used in Pharmaceutical Industry:
4-Methoxy-3,5-diMethylpicolinonitrile is used as a reactant in the synthesis of 2-[(3,5-dimethyl-4-methoxypyridinyl)alkyl]benzothiazolidine derivatives, which serve as gastric H+/K+-ATPase inhibitors. These inhibitors play a crucial role in the treatment of gastric ulcers and other gastrointestinal disorders by reducing the secretion of gastric acid.
1. Source: The use of 4-Methoxy-3,5-diMethylpicolinonitrile as a reactant in the synthesis of gastric H+/K+-ATPase inhibitors is mentioned in the provided materials.

Upstream product

• 187222-21-5 2-Carboxamide-3,5-Dimethyl-4-Methoxypyridine 
• 86604-78-6 (4-methoxy-3,5-dimethylpyridin-2-yl)methanol 
• 110464-72-7 4-methoxy-3,5-dimethyl-2-pyridinecarboxaldehyde 
• 187222-13-5 3,5-Dimethyl-2-ethoxycarbonyl-4-pyrone 
• 187222-20-4 2-Carboxamide-3,5-Dimethyl-4(1H)-Pyridone 
• 187222-12-4 3,5-dimethyl-4-oxo-4H-pyran-2-carboxylic acid 
• 187222-11-3 1-ethoxy-2-methylpent-1-en-3-one 
• 50421-81-3 1-hydroxy-2-methyl-1-penten-3-one 

Downstream Products

• 86604-75-3 2-(chloromethyl)-4-methoxy-3,5-dimethylpyridine hydrochloride 
• 130000-78-1 (4-methoxy-3,5-dimethylpyridin-2-yl)methanamine 

Relevant academic research and scientific papers

A Transition-Metal-Free One-Pot Cascade Process for Transformation of Primary Alcohols (RCH2OH) to Nitriles (RCN) Mediated by SO2F2

A new transition-metal-free one-pot cascade process for the direct conversion of alcohols to nitriles was developed without introducing an “additional carbon atom”. This protocol allows transformations of readily available, inexpensive, and abundant alcohols to highly valuable nitriles.

Synthesis of 2-hydroxymethyl-3,5-dimethyl-4-methoxypyridine : A key intermediate for omeprazole

A synthesis of 2-hydroxymethyl-3,5-dimethyl-4-methoxypyridine, a key intermediate for the preparation of gastric acid inhibiting compound omeprazole, is described. The procedure consists of preparation of pyrone, pyridone and pyridine derivatives sequentially.

Process for preparing 2-cyano-3,5-dimethyl-4-methoxypyridine

A process of preparing 2-cyano-3,5-dimethyl-4-methoxypyridine. The process includes the steps of: acylating 2-methyl-1-penten-1-alkoxy-3-one to obtain 2-alkoxycarbonyl-3,5-dimethyl-4-pyrone; ammonolyzing 2-alkoxycarbonyl-3,5-dimethyl-4-pyrone to obtain 2-carboxamido-3,5-dimethyl-4(1H)-pyridone; methylating 2-carboxamido-3,5-dimethyl-4(1H)-pyridone to obtain 2-carboxamido-3,5-dimethyl-4-methoxypyridine; and dehydrating said 2-carboxamido-3,5-dimethyl-4-methoxypyridone to obtain 2-cyano-3,5-dimethyl-4-methoxypyridine.

3,5-dimethyl-4-methoxypyridine derivatives

A process for the preparation of compounds of formula I STR1 in which X is the radical OH or Cl, by the catalytic hydrogenation of 3,5-dimethyl-4-methoxy-2-cyanopyridine, subsequent reaction of the resulting 3,5-dimethyl-4-methoxy-2-aminomethylpyridine to give 3,5-dimethyl-4-methoxy-2-hydroxymethylpyridine and, if desired, chlorination to give 3,5-dimethyl-4-methoxy-2-chloromethylpyridine, and the novel intermediate 3,5-dimethyl-4-methoxy-2-aminomethylpyridine.