10493-09-1

Basic information

• Product Name: 7,3',4'-trimethoxyflavanone
• Synonyms: 7,3',4'-trimethoxyflavanone
• CAS NO: 10493-09-1
• Molecular Weight: 314.338
• Mol File: 10493-09-1.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 7,3',4'-trimethoxyflavanone(CAS DataBase Reference)
• NIST Chemistry Reference: 7,3',4'-trimethoxyflavanone(10493-09-1)
• EPA Substance Registry System: 7,3',4'-trimethoxyflavanone(10493-09-1)

Safety Data

• Hazardous Substances Data: 10493-09-1(Hazardous Substances Data)

Upstream product

• 75-11-6 diiodomethane 
• 57601-14-6 2'-hydroxy-3,4,4'-trimethoxychalcone 
• 107-00-6 but-1-yne 
• 77-78-1 dimethyl sulfate 
• 503-17-3 dimethylacetylene 
• 552-41-0 1-(2-hydroxy-4-methoxyphenyl)ethanone 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 35090-88-1 (+)-3',4',7-tri-O-methylfustin 
• 4382-36-9 (+)-Fustin 
• 74645-71-9 3′,4′,7-trimethoxyflavanone 
• 10493-06-8 3-(3,4-dimethoxyphenyl)-1-(2-hydroxy-4-methoxyphenyl)-2-propen-1-one 
• 76672-90-7 3-(3,4-dimethoxyphenyl)-1-(2-hydroxy-4-methoxyphenyl)-1-propanone 
• 150-19-6 O-methylresorcine 
• 122775-35-3 3,4-Dimethoxyphenylboronic acid 

Downstream Products

• 22395-24-0 3',4',7-trimethoxyflavone 
• 20046-13-3 7,3',4'-trimethoxyflavan-4-ol 
• 1621-61-0 cabreuvin 
• 1266399-43-2 4-(3,4-dimethoxyphenyl)-7-methoxy-4H-benzopyran[4,3-d][1,2,3]selenadiazole 
• 1266399-53-4 C₁₉H₂₁N₃O₅ 
• 138469-49-5 C₂₅H₂₅NO₇S 
• 20046-13-3 trans-4-hydroxy-3',4',7-trimethoxyflavan 
• 20046-13-3 cis-4-hydroxy-3',4',7-trimethoxyflavan 
• 21913-99-5 2-(3,4-dihydroxyphenyl)-7-hydroxychroman-4-one 

Relevant articles and documents

Divergent synthesis of flavones and flavanones from 2′-hydroxydihydrochalconesviapalladium(ii)-catalyzed oxidative cyclization

Divergent and versatile synthetic routes to flavones and flavanonesviaefficient Pd(ii) catalysis are disclosed. These Pd(ii) catalyses expediently provide a variety of flavones and flavanones from 2′-hydroxydihydrochalcones as common intermediates, depending on oxidants and additives,viadiscriminate oxidative cyclization sequences involving dehydrogenation, respectively, in a highly atom-economic manner.

Synthesis and cytotoxic activity of 4-aryl-4H-chromeno[4,3-d] [1,2,3] selenadiazoles

Fourteen 4-Aryl-4H-chromeno[4,3-d][1,2,3] selenadiazole derivatives were synthesized by the reaction of fla-vonone-4-semicarbazones with SeO2. The structures of the target compounds 1a-n were elucidated by 1H NMR, IR spectra, ESI-MS and elemental analyses. The preliminary cytotoxic activities of 1a-n against K562, KB, A549, SMC-7721 and SGC-7901 cell lines were evaluated by MTT method, indicating that most compounds displayed moderate to good antiproliferative activities against K562 and KB cell lines. Compounds 1m and 1n, the most potent ones, were promising template for development of novel potent antitumor agents.

Synthesis of isoflavones containing naturally occurring substitution pattern by oxidative rearrangement of respective flavanones using thallium(III) p-tosylate

Claisen condensation of substituted 2′-hydroxyacetophenones 1a-c with aromatic aldehydes affords respective substituted 2′-hydroxychalcones 2a-n which on base catalyzed cyclization in pyridine:methanol:water (1:1:1) give respective flavanones 3a-n. The oxidative rearrangement of flavanones with thallium(III) p-tosylate furnishes respective isoflavones 4a-n in overall 62-72% yields starting from 1. The present methodology has been successfully applied for the synthesis of naturally occurring isoflavones such as di-O-methyldaidzein 4a, cabruvin 4b, pseudobabtigenin methylether 4d, 5,7-dimethoxyisoflavone 4f, 5,7,4′-trimethoxyisoflavone 4g, derrustone 4i, 7,8,3′,4′- tetramethoxyisoflavone 41, purpuranin-A 4m and 7,8,3′,4′,5′- pentamethoxyisoflavone 4n and thus the first synthesis of 4n is reported.