21913-99-5Relevant articles and documents
COMPOSITION FOR INDUCING DIFFERENTIATION INTO BEIGE AND BROWN ADIPOCYTES AND METHOD OF INDUCING THE SAME
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Paragraph 0119-0121, (2016/03/29)
A composition for inducing differentiation into beige adipocytes from white adipocytes, including butein, a butein derivative, or a pharmaceutically available salt thereof as an active ingredient, and a method of inducing the differentiation are provided. Increases in expressions of UCP-1 and PRDM4 are confirmed using the active ingredient, that is, the butein or butein derivative, and therefore the composition is expected to be used in preventing or treating obesity, and more basically, for target treatment.
Polyphenols from the bark of Rhus verniciflua and their biological evaluation on antitumor and anti-inflammatory activities
Kim, Ki Hyun,Moon, Eunjung,Choi, Sang Un,Kim, Sun Yeou,Lee, Kang Ro
, p. 113 - 121 (2013/10/21)
Bioassay-guided fractionation and chemical investigation of the extract of Rhus verniciflua bark resulted in the identification of six polyphenols, rhusopolyphenols A-F (1-6), together with four known compounds including (2R,3S,10S)-7,8,9,13-tetrahydroxy-2-(3,4-dihydroxyphenyl)-2,3-trans-3,4-cis-2,3, 10-trihydrobenzopyrano[3,4-c]-2-benzopyran-1-one (7), peapolyphenol C (8), cilicione-b (9) and (αR)- α,3,4,2',4'-pentahydroxydihydrochalcone (10). The structures of these polyphenols were elucidated by spectroscopic analysis, including 1D and 2D NMR, and HR-ESIMS, and their absolute configurations were further confirmed by a combination of chemical methods and CD data analysis. All isolates were evaluated for their antiproliferative activities against four human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and HCT-15), and compounds 4-6, 9 and 10 showed antiproliferative activity against the tested cells, with IC50 values of 3.31-18.51 μM. On the basis of the expanded understanding that inflammation is a crucial cause of tumor progression, the anti-inflammatory activities of these compounds were determined by measuring nitric oxide (NO) levels in the medium of murine microglia BV-2 cells. Compounds 5 and 10 significantly inhibited NO production in lipopolysaccharide (LPS)-stimulated murine microglia BV-2 cells with IC 50 values of 28.90 and 12.70 μM, respectively.
Bioactive flavonoids of the flowers of Butea monosperma
Chokchaisiri, Ratchanaporn,Suaisom, Channarong,Sriphota, Siriluk,Chindaduang, Anon,Chuprajob, Thipphawan,Suksamrarn, Apichart
experimental part, p. 428 - 432 (2009/12/27)
One new dihydrochalcone, dihydromonospermoside (7), was isolated from the flowers of Butea monosperma together with three known chalcones, butein (2), monospermoside (4) and isoliquiritigenin (8), one flavone, 7,3',4'- trihydroxyflavone (6), four flavanon
Antioxidant study and assignments of NMR spectral data for 3′,4′,7-trihydroxyflavanone 3′,7-Di-O-β-D-glucopyranoside (butrin) and its hydrolyzed product
Jassbi, Amir Reza,Singh, Pahup,Krishna, Vivek,Gupta, Pradeep K.,Tahara, Satoshi
, p. 250 - 253 (2007/10/03)
The NMR spectral data including high resolution 1H, 13C and 2D NMR for butrin, 3′,4′,7-trihydroxyflavanone 3′,7-di-O-β-D-glucopyranoside, isolated from flowers of Butea monosperma, are reported here for the first time. Butrin was hydrolyzed using b-glucosidase to butin in high yield. They were subjected to free radical scavenging test using 2,2-diphenyl-1-picrylhydrazyl (DPPH) spectrophotometric assay. At a dose of 4 × 10-8 mol of tested compounds, the percentage of reduced DPPH for butin was 14.5% while no reduction was observed for butrin (0%).
A Convient Synthesis of Polyhydroxylated Chalcones and Flavanones
Ahluwalia, Vinod K.,Khanduri, Chandra H.,Mehta, Vimal D.,Sharma, Narain D.
, p. 67 (2007/10/02)
A convenient route has been described for the synthesis of polyhydroxy chalcones and flavanones involving demethylation of their methyl ethers with pyridinium bromide.
Photochemical Deoxygenation of an α-Ketol: The Dihydroflavonol-Flavanone Conversion
Westhuizen, Jan H. van der,Ferreira, Daneel,Roux, David G.
, p. 1003 - 1006 (2007/10/02)
Irradiation of optically pure 2,3-trans-3-hydroxyflavanones in anhydrous ethyl acetate leads directly to free phenolic flavanone analogues with complete retention of configuration at C(2).Similarly their methyl ethers give the corresponding flavanones and flavones.The reaction represents the photochemical equivalent of a reduction under Clemmensen conditions.
