4382-36-9

Basic information

• Product Name: 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,7-dihydroxy-, (2R,3R)-
• Synonyms: fustin;3,7,3',4'-tetrahydroxyflavone;Fustine;3,3',4',7-tetrahydroxyflavanone;3,7,3',4'-tetrahydroxyflavanone
• CAS NO: 4382-36-9
• Molecular Formula: C15H12O6
• Molecular Weight: 288.257
• Mol File: 4382-36-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,7-dihydroxy-, (2R,3R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,7-dihydroxy-, (2R,3R)-(4382-36-9)
• EPA Substance Registry System: 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,7-dihydroxy-, (2R,3R)-(4382-36-9)

Safety Data

• Hazardous Substances Data: 4382-36-9(Hazardous Substances Data)

Upstream product

• 487-52-5 3,4,2',4'-tetrahydroxy-chalcone 
• 89-84-9 2',4'-dihydroxy-4-acetophenone 
• 139-85-5 3,4-dihydroxybenzaldehyde 
• 124775-23-1 tetrakis(O-methoxymethyl)butein 
• 6515-06-6 3,4-bis-methoxymethoxy-benzaldehyde 
• 6515-05-5 2',4'-bis(methoxymethoxy)acetophenone 
• 487-52-5 butein 

Downstream Products

• 74645-71-9 3′,4′,7-trimethoxyflavanone 
• 10493-09-1 7,3',4'-trimethoxyflavanone 
• 22395-24-0 3',4',7-trimethoxyflavone 
• 57601-14-6 2'-hydroxy-3,4,4'-trimethoxychalcone 
• 114619-78-2 (+/-)-3t,7-Diacetoxy-2r-(3,4-diacetoxy-phenyl)-chroman-4c-ol 
• 20772-33-2 (+/-)-mollisacacidin pentaacetate 
• 21913-99-5 (2S)-2-(3,4-dihydroxyphenyl)-2,3-dihydro-7-hydroxy-4H-chromen-4-one 
• 35090-88-1 (+)-3',4',7-tri-O-methylfustin 
• 528-48-3 3,7,3',4'-tetrahydroxyflavone 
• 6515-24-8 (+/-)-2,3-trans-3-hydroxy-3',4',7-trimethoxyflavan 
• 6515-23-7 (+/-)-fustin tetraacetate 

Relevant articles and documents

Design, synthesis and anti-inflammatory activity of dihydroflavonol derivatives

Thirty dihydroflavonol derivatives (D1–D30) were designed and synthesized, meanwhile the synthesized compounds were characterized on the basis of spectroscopic analyzes. Their inhibitory activity against the pro-inflammatory inducible interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) in lipopolysaccharide (LPS)-stimulated murine RAW 264.7 macrophages were evaluated and showed various efficiency. Compounds D1–D30 showed no toxic effects on RAW 264.7 cells at the concentration 20 μM; among them, compounds D9, D13, and D19 exhibited best anti-inflammatory activity through decreasing IL-1β, IL-6, and TNF-α. Furthermore, their structure–activity relationships were discussed preliminarily.

HETEROCYCLES. XVIII. SYNTHESIS OF THE RACEMATES OF NATURALLY OCCURRING FLAVONOIDS

Racemic aromadendrin and fustin have been stereoselectively synthesized.Reduction of the O-substituted derivatives of these flavanonols provides the corresponding derivatives of gleditsin, leucopelargonidin and mollisacacidin (leucofisetinidin).