10495-37-1

Usage

Uses

Used in Pharmaceutical Development:
1H-benz[de]isoquinoline-1,3(2H)-dione, 6-amino-2-phenylis used as a potential antitumor agent for its inhibitory effects on the proliferation of cancer cells. Its unique structure and properties make it a promising candidate for the development of new cancer therapies.
Used in Cancer Research:
In the field of cancer research, 1H-benz[de]isoquinoline-1,3(2H)-dione, 6-amino-2-phenylis utilized to study the mechanisms of action and potential synergistic effects with other chemotherapeutic drugs, aiming to enhance the efficacy and chemo-sensitivity of cancer treatments.
Used in Biochemistry and Molecular Biology:
1H-benz[de]isoquinoline-1,3(2H)-dione, 6-amino-2-phenylis employed as a fluorescent probe for the detection and analysis of DNA and RNA. Its unique properties allow for the visualization and study of nucleic acid structures and interactions, contributing to advancements in molecular biology and genomics research.
Used in Drug Delivery Systems:
To improve the bioavailability and therapeutic outcomes of 1H-benz[de]isoquinoline-1,3(2H)-dione, 6-amino-2-phenyl-, various drug delivery systems, including organic and metallic nanoparticles, have been developed. These systems aim to enhance the compound's delivery to target cells and tissues, increasing its efficacy and reducing potential side effects.

InChI:InChI=1/C18H12N2O2/c19-15-10-9-14-16-12(15)7-4-8-13(16)17(21)20(18(14)22)11-5-2-1-3-6-11/h1-10H,19H2

Upstream product

• 42340-35-2 6-nitro-2-phenylbenzo[d,e]isoquinoline-1,3-dione 
• 602-87-9 4-nitroacenaphthene 
• 6642-29-1 4-nitronaphthalic-1,8-anhydride 
• 83-32-9 acenaphthene 
• 62-53-3 aniline 

Downstream Products

• 20119-29-3 4-(acetylamino)-N-phenyl-1,8-naphthalimide 
• 1128246-35-4 C₂₃H₁₅F₈N₂O₅P 
• 1128246-39-8 C₂₄H₂₃N₂O₅P 
• 1128246-31-0 N-phenyl-4-[α-(diethylphosphoryl)benzylamino]naphthalimide 
• 101968-95-0 C₃₆H₂₅N₂O₂P 
• 796-04-3 4-hydroxy-N-phenyl-1,8-naphthalimide 

Relevant academic research and scientific papers

METHODS AND COMPOSITIONS FOR TREATING BETA-THALASSEMIA AND SICKLE CELL DISEASE

Compounds, pharmaceutical compositions, and methods for treating anemia β-thalassemia anemia or sickle cell anemia.

Methods and compositions for treating beta-thalassemia and sickle cell disease

Compounds, pharmaceutical compositions, and methods for treating anemia beta-thalassemia anemia or sickle cell anemia are disclosed.

Isomeric naphthalimides bearing pyran units: Insight into mutual relation between structure and photochromic properties

Two novel isomeric photochromic naphthopyrans (1 and 2) containing naphthalimide moieties were prepared and studied. In the compound 1, O-atom of pyran cycle is at C-3 position of naphthalene ring, whereas, in compound 2, O-atom of pyran cycle is at C-4 position. In the compound 2 due to para-position O-atom of pyran photochrome cycle is involved into the conjugated naphthalimide system. The variety in mutual position of pyran and naphthalimide units leads to remarkable difference in photochromic characteristics. Both compounds demonstrate the switching of the fluorescence by photoinduced conversion between the closed and open forms.

Synthesis and spectral properties of 4-amino-and 4-acetylamino-N- arylnaphthalimides containing electron-donating groups in the N-aryl substituent

A method for the synthesis of N-aryl-substituted 4-amino-and 4-acetylaminonaphthalimide derivatives with mono-and dialkoxy groups or a 15-crown-5 moiety in the N-aryl substituent is described. The introduction of electron-donating alkoxy groups into the benzene ring of the N-aryl fragment results in fluorescence quenching of the naphthalimide chromophore, which is most pronounced in the spectra of N-acetyl derivatives. The photophysical properties of the synthesized 4-amino-and 4-acetylaminonaphthalimides depend on the solvent polarity and its specific solvating ability due to H-bonding. The crown-containing compounds are promising fluorescent chemosensors for metal cations. ; 2009 Springer Science+Business Media, Inc.