42340-35-2Relevant academic research and scientific papers
METHODS AND COMPOSITIONS FOR TREATING BETA-THALASSEMIA AND SICKLE CELL DISEASE
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Paragraph 0221; 0222; 0223, (2016/05/19)
Compounds, pharmaceutical compositions, and methods for treating anemia β-thalassemia anemia or sickle cell anemia.
Methods and compositions for treating beta-thalassemia and sickle cell disease
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Paragraph 0289; 0290; 0291; 0292; 0293; 0294, (2016/10/08)
Compounds, pharmaceutical compositions, and methods for treating anemia beta-thalassemia anemia or sickle cell anemia are disclosed.
Isomeric naphthalimides bearing pyran units: Insight into mutual relation between structure and photochromic properties
Fedorova,Sergeeva,Panchenko,Fedorov, Yu. V.,Erko,Berthet,Delbaere
, p. 28 - 35 (2015/03/04)
Two novel isomeric photochromic naphthopyrans (1 and 2) containing naphthalimide moieties were prepared and studied. In the compound 1, O-atom of pyran cycle is at C-3 position of naphthalene ring, whereas, in compound 2, O-atom of pyran cycle is at C-4 position. In the compound 2 due to para-position O-atom of pyran photochrome cycle is involved into the conjugated naphthalimide system. The variety in mutual position of pyran and naphthalimide units leads to remarkable difference in photochromic characteristics. Both compounds demonstrate the switching of the fluorescence by photoinduced conversion between the closed and open forms.
Assembly of New Merocyanine Chromophores with a 1,8-Naphthalimide Core by a New Method for the Synthesis of the Methine Function
Vasilev, Aleksey A.,Baluschev, Stanislav,Cheshmedzhieva, Diana,Ilieva, Sonia,Casta?o, Obis D.,Vaquero, Juan J.,Angelova, Silvia E.,Landfester, Katharina
, p. 1399 - 1408 (2015/09/15)
A new method for the synthesis of the monomethine group using nitro as a leaving group in an SN-Ar reaction is described. A series of novel merocyanine dyes has been synthesised and their photophysical properties have been elucidated. The longest wavelength absorption occurs in the range 519-619nm and the molar absorptivities vary with the substituents and are in the range 1000-47700Lmol-1cm-1. The dyes show high chemical and photostability. One example from the series has the ability to distinguish methanol from ethanol. The introduction of a quinoid fragment into the structure leads to a pronounced intramolecular charge transfer and hence a noticeable positive solvatochromism. The structures and electronic properties of the compounds have been studied by density functional theory (DFT) and time-dependent DFT.
Synthesis and spectral properties of 4-amino-and 4-acetylamino-N- arylnaphthalimides containing electron-donating groups in the N-aryl substituent
Panchenko,Fedorova,Perevalov,Jonusauskas,Fedorov
experimental part, p. 1233 - 1240 (2010/10/04)
A method for the synthesis of N-aryl-substituted 4-amino-and 4-acetylaminonaphthalimide derivatives with mono-and dialkoxy groups or a 15-crown-5 moiety in the N-aryl substituent is described. The introduction of electron-donating alkoxy groups into the benzene ring of the N-aryl fragment results in fluorescence quenching of the naphthalimide chromophore, which is most pronounced in the spectra of N-acetyl derivatives. The photophysical properties of the synthesized 4-amino-and 4-acetylaminonaphthalimides depend on the solvent polarity and its specific solvating ability due to H-bonding. The crown-containing compounds are promising fluorescent chemosensors for metal cations. ; 2009 Springer Science+Business Media, Inc.
The Synthesis of Alkylamino-N-alkylnaphthalic-1,8-imides from 2- and 4-nitronaphthalic Anhydrides by Nitro group Displacement
Alexiou, Michael S.,Tyman, John H. P.
, p. 632 - 652 (2007/10/03)
4-Alkylamino-N-alkylnaphthalic-1,8-imides and 2-alkylamino isomers have been synthesised by the reaction of 4-nitro- and 2-nitronaphthalic anhydrides respectively with primary amines in aprotic solvents in which reaction the nitro group in 3-nitronaphthalic anhydride is unreactive. Unsymmetrical compounds in the 2- and 4-series are derived from either the appropriate 4-nitro-N-alkylnaphthalic-1,8-imide or for 4-dilakylamino compounds from 4-nitronaphthalic anhydride by reaction with a secondary amine and then the 4-dialkylaminonaphthalic anhydride with a primary amine.
Synthesis and properties of fluorescent 1,8-naphthalimide dyes for application in liquid crystal displays
Grabchev, Ivo,Moneva, Ivanka,Bojinov, Vladimir,Guittonneau, Sylvie
, p. 1291 - 1296 (2007/10/03)
A series of highly fluorescent 1,8-naphthalimide derivatives having an N-allylamino group at position 4 of the aromatic structure have been synthesised, and some of their properties for application in liquid crystal displays have been determined. The opti
