104970-97-0

Upstream product

• 20628-07-3 2-acetyl-4-methylanisole 
• 104971-07-5 2-ethynyl-1-methoxy-4-methylbenzene 
• 104-93-8 p-methylanizole 
• 1450-72-2 5-methyl-2-hydroxyacetophenone 
• 64-17-5 ethanol 
• 141-52-6 sodium ethanolate 

Downstream Products

• 104971-14-4 1-Methoxy-4-methyl-2-oct-1-ynyl-benzene 
• 104971-07-5 2-ethynyl-1-methoxy-4-methylbenzene 

Relevant academic research and scientific papers

Catalyst-free hydrochlorination protocol for terminal arylalkynes with hydrogen chloride

We present a simple and straightforward protocol for hydrochlorination of terminal arylalkynes to vinyl chlorides using hydrogen chloride under mild reaction conditions. This protocol does not involve any metal catalysts or additives. It is simple, inexpensive, and easy to prepare, and exhibits good reaction activity. The hydrochlorination proceeds smoothly to yield unique regioselective products via the Markovnikov addition rule.

A Versatile Two-Stage Synthesis of 2-Substituted Benzofurans from (2-Methoxyphenyl)ethynes

(2-Methoxyphenyl)ethynes react with aryl or alkyl halides to give disubstituted alkynes which are converted into the corresponding 2-substituted benzofurans on treatment with lithium iodide in 2,4,6-trimethylpyridine.