1049809-94-0

Basic information

• Product Name: N-(4-chlorobenzyl)(4-ethynylphenyl)methanamine
• Synonyms: N-(4-chlorobenzyl)(4-ethynylphenyl)methanamine;N-(4-chlorobenzyl)-1-(4-ethynylphenyl)methanamine;(4-Chlorobenzyl)(4-ethynylbenzyl)amine;4-Chloro-N-[(4-ethynylphenyl)methyl]benzenemethanamine
• CAS NO: 1049809-94-0
• Molecular Formula: C₁₆H₁₄ClN
• Molecular Weight: 255.08
• Mol File: 1049809-94-0.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: N-(4-chlorobenzyl)(4-ethynylphenyl)methanamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-chlorobenzyl)(4-ethynylphenyl)methanamine(1049809-94-0)
• EPA Substance Registry System: N-(4-chlorobenzyl)(4-ethynylphenyl)methanamine(1049809-94-0)

Safety Data

• Hazardous Substances Data: 1049809-94-0(Hazardous Substances Data)

Usage

General Description

N-(4-chlorobenzyl)(4-ethynylphenyl)methanamine is a chemical compound with the molecular formula C18H14ClN. It is a derivative of benzylamine and ethynylbenzene, and it contains a chlorobenzyl and ethynylphenyl group. This chemical is commonly used in pharmaceutical research and drug development as a potential candidate for developing new medications, particularly in the field of central nervous system disorders. Its specific biological and pharmacological properties are of interest in the investigation of potential treatments for various medical conditions. The chemical's structure and properties make it a versatile and valuable tool in the development of potential therapeutic agents.

Upstream product

• 63697-96-1 4-Ethynylbenzaldehyde 
• 104-86-9 4-chlorobenzylamine 
• 77123-57-0 4-[(trimethylsilyl)ethynyl]bezaldehyde 

Downstream Products

• 1049808-54-9 (4-Chloro-benzyl)-(4-{2-chloro-5-[5-methanesulfonyl-1-(3-morpholin-4-yl-propyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]-phenylethynyl}-benzyl)-amine 
• 1181359-24-9 2-{3-(4-chloro-3-{4-[(4-chloro-benzylamino)-methyl]-phenylethynyl}-phenyl)-1-[3-(3-methyl-morpholin-4-yl)-propyl]-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-5-yl}-2-oxo-acetamide L-tartrate 
• 1422264-36-5 C₂₁H₂₂ClNO₂ 
• 1049809-77-9 C₁₈H₁₃ClF₃NO 
• 1422264-37-6 C₃₈H₃₉Cl₂N₅O₅ 
• 1049810-13-0 (4-[5-[5-Carbamoyl-(3-hydroxy-propyl)-4,5,6,7-tetrahydro-1 H-pyrazolo[4,3-c]pyridin-3-yl]-2-chloro-phenylethynyl]-benzyl)-(4-chloro-benzyl)-carbamic acid tert-butyl ester 
• 1049817-58-4 3-(4-Chloro-3-{[4-({[(4-chlorophenyl)methyl]amino}methyl)phenyl]ethynyl}phenyl)-N-methyl-1-(3-morpholin-4-ylpropyl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxamide 
• 1049809-78-0 N-(4-chloro-benzyl)-N-(4-{2-chloro-5-[1-(3-morpholin-4-yl-propyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]phenylethynyl}-benzyl)-2,2,2-trifluoro-acetamide 
• 1049817-50-6 3-(4-chloro-3-((4-((((4-chlorophenyl)methyl)amino)methyl)phenyl)ethynyl)phenyl)-1-(3-morpholin-4-ylpropyl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxamide 
• 1049813-33-3 3-(4-chloro-3-((4-((((4-chlorophenyl)methyl)amino)methyl)phenyl)ethynyl)phenyl)-1-(3-((3S)-3-methylmorpholin-4-yl)propyl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxamide 
• 1049810-02-7 1-[4-({2-Chloro-5-[1-(3-morpholin-4-ylpropyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]phenyl}ethynyl)phenyl]-N-[(4-chlorophenyl)methyl]methanamine 
• 1049817-65-3 C₃₆H₃₈Cl₂N₆OS 

Relevant articles and documents

Pyrazole-based arylalkyne Cathepsin S inhibitors. Part III: Modification of P4 region

Novel classes of tetrahydropyrido-pyrazole thioether amines and arylalkynes that display potency against human Cathepsin S have been previously reported. Here, key pharmacophoric elements of these two classes are merged, and SAR investigations of the P4 region are described, in conjunction with re-optimization of the P5 and P1/P1′/P3 regions. Identification of meta-substituted arylalkynes with good potency and improved solubility is described.

PROCESSES FOR THE PREPARATION OF CARBON-LINKED TETRAHYDRO-PYRAZOLO-PYRIDINE MODULATORS OF CATHEPSIN S

Method of making carbon-linked tetrahydro-pyrazolo-pyridine compounds of the following Formula (I) and pharmaceutically acceptable salts thereof: comprising reacting a compound of formula (IX): with a compound of formula (X): to form a compound of Formula

CARBON-LINKED TETRAHYDRO-PYRAZOLO-PYRIDINE MODULATORS OF CATHEPSIN S

Carbon-linked tetrahydro-pyrazolo-pyridine compounds are described, which are useful as cathepsin S modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by cathepsin S activity, such as psoriasis, pain, multiple sclerosis, atherosclerosis, and rheumatoid arthritis.