1050-28-8

Basic information

• Product Name: H-TYR-TYR-OH
• Synonyms: tyrosyltyrosine;L-TYROSYL-L-TYROSINE;H-TYR-TYR-OH;TYR-TYR;TYR-TYR CRYSTALLINE;(2S)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-3-(4-hydroxyphenyl)propanoic acid;(2S)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-3-(4-hydroxyphenyl)propionic acid;(2S)-2-[[(2S)-2-azanyl-3-(4-hydroxyphenyl)propanoyl]amino]-3-(4-hydroxyphenyl)propanoic acid
• CAS NO: 1050-28-8
• Molecular Formula: C₁₈H₂₀N₂O₅
• Molecular Weight: 344.36
• Mol File: 1050-28-8.mol
• Article Data: 4

Chemical Properties

• Melting Point: 300 °C (decomp)
• Boiling Point: 703.1°Cat760mmHg
• Flash Point: 379°C
• Appearance: /
• Density: 1.372g/cm³
• Vapor Pressure: 9.55E-21mmHg at 25°C
• Refractive Index: 1.647
• Storage Temp.: -15°C
• PKA: pK1:3.52(+1);pK2:7.68(0);pK3:9.80(+1);pK4:10.26(+2) (25°C)
• CAS DataBase Reference: H-TYR-TYR-OH(CAS DataBase Reference)
• NIST Chemistry Reference: H-TYR-TYR-OH(1050-28-8)
• EPA Substance Registry System: H-TYR-TYR-OH(1050-28-8)

Safety Data

• Hazardous Substances Data: 1050-28-8(Hazardous Substances Data)

Usage

Uses

H-TYR-TYR-OH (cas# 1050-28-8) is an antihypertensive peptide with angiotensin I-converting enzyme (ACE) inhibitory activity prepared from the powder of the jellyfish.

Definition

ChEBI: Tyrosyltyrosine in which each tyrosine residue has L-configuration.

InChI:InChI=1/C18H20N2O5/c19-15(9-11-1-5-13(21)6-2-11)17(23)20-16(18(24)25)10-12-3-7-14(22)8-4-12/h1-8,15-16,21-22H,9-10,19H2,(H,20,23)(H,24,25)

Upstream product

• 10417-83-1 N-(N-benzyloxycarbonyl-L-tyrosyl)-L-tyrosine 
• 4455-26-9 methyldioctylamine 
• 23224-65-9 L-Tyr(OAc) NCA 
• 949-67-7 L-tyrosine ethyl ester 
• 1080-06-4 L-Tyr-OMe 
• 4985-46-0 L-Tyr-NH₂ 
• 60-18-4 L-tyrosine 
• 51514-13-7 O-acetyl-N-benzyloxycarbonyl L-tyrosine 
• 6425-74-7 N-(O-acetyl-N-benzyloxycarbonyl-L-tyrosyl)-L-tyrosine ethyl ester 
• 51514-08-0 O-acetyl-N-benzyloxycarbonyl-L-tyrosyl chloride 

Downstream Products

• 14191-95-8 4-cyanomethylphenol 
• 538-86-3 benzyl methyl ether 
• 60-18-4 L-tyrosine 

Relevant articles and documents

A dynamic combinatorial library for biomimetic recognition of dipeptides in water

Small peptides are involved in countless biological processes. Hence selective binding motifs for peptides can be powerful tools for labeling or inhibition. Finding those binding motifs, especially in water which competes for intermolecular H-bonds, poses an enormous challenge. A dynamic combinatorial library can be a powerful method to overcome this issue. We previously reported artificial receptors emerging form a dynamic combinatorial library of peptide building blocks. In this study we aimed to broaden this scope towards recognition of small peptides. Employing CXC peptide building blocks, we found that cyclic dimers of oxidized CFC bind to the aromatic peptides FF and YY (K ≈ 229-702 M-1), while AA binds significantly weaker (K ≈ 65-71 M-1).

Peptide bond formation by aminolysin-A catalysis: A simple approach to enzymatic synthesis of diverse short oligopeptides and biologically active puromycins

A new S9 family aminopeptidase derived from the actinobacterial thermophile Acidothermus cellulolyticus was cloned and engineered into a transaminopeptidase by site-directed mutagenesis of catalytic Ser491 into Cys. The engineered biocatalyst, designated aminolysin-A, can catalyze the formation of peptide bonds to give linear homo-oligopeptides, hetero-dipeptides, and cyclic dipeptides using cost-effective substrates in a one-pot reaction. Aminolysin-A can recognize several C-terminal-modified amino acids, including the l- and d-forms, as acyl donors as well as free amines, including amino acids and puromycin aminonucleoside, as acyl acceptors. The absence of amino acid esters prevents the formation of peptides; therefore, the reaction mechanism involves aminolysis and not a reverse reaction of hydrolysis. The aminolysin system will be a beneficial tool for the preparation of structurally diverse peptide mimetics by a simple approach.