1050211-07-8

Basic information

• Product Name: (S)-3-[5-fluoro-1-(2-fluoro-phenyl)-1H-indazol-3-yloxymethyl]-piperidine-1-carboxylic acid tert-butyl ester
• Synonyms: (S)-3-[5-fluoro-1-(2-fluoro-phenyl)-1H-indazol-3-yloxymethyl]-piperidine-1-carboxylic acid tert-butyl ester
• CAS NO: 1050211-07-8
• Molecular Weight: 443.493
• Mol File: 1050211-07-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (S)-3-[5-fluoro-1-(2-fluoro-phenyl)-1H-indazol-3-yloxymethyl]-piperidine-1-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3-[5-fluoro-1-(2-fluoro-phenyl)-1H-indazol-3-yloxymethyl]-piperidine-1-carboxylic acid tert-butyl ester(1050211-07-8)
• EPA Substance Registry System: (S)-3-[5-fluoro-1-(2-fluoro-phenyl)-1H-indazol-3-yloxymethyl]-piperidine-1-carboxylic acid tert-butyl ester(1050211-07-8)

Safety Data

• Hazardous Substances Data: 1050211-07-8(Hazardous Substances Data)

Upstream product

• 321-69-7 5-fluoroisatoic anhydride 
• 2924-15-4 (2-fluorophenyl)hydrazine hydrochloride 
• 4606-65-9 3-(hydroxymethy)piperidine 
• 888952-51-0 2-amino-5-fluoro-N'-(2-fluorophenyl)benzohydrazide 
• 2368-80-1 2-fluorophenylhydrazine 
• 888952-52-1 5-fluoro-1-(2-fluorophenyl)-1H-indazol-3-ol 
• 364356-44-5 (S)-<<(methylsulfonyl)oxy>methyl>piperidine-1-carboxylic acid tert-butyl ester 
• 140695-84-7 tert-butyl (3S)-3-(hydroxymethyl)piperidine-1-carboxylate 
• 446-08-2 2-amino-5-fluorobenzoic acid 

Downstream Products

• 888951-64-2 C₁₉H₁₉F₂N₃O 

Relevant articles and documents

The synthesis of (S)-5-fluoro-1-(2-fluorophenyl)-3-(piperidin-3-ylmethoxy)- 1H-indazole, a norepinephrine/serotonin reuptake inhibitor for the treatment of fibromyalgia

Compound 1, a norepinephrine/serotonin reuptake inhibitor (NSRI) for the treatment of fibromyalgia, has been synthesized in optically pure form in six linear steps and 48% overall yield with no chromatography. This route features a novel and efficient intramolecular cyclization to generate the indazolone core via a diazotization reaction and the preparation of a stable polymorph of the tartaric acid salt as the desired final form. The original synthetic route has been modified to avoid the use of toxic and expensive reagents, thus enabling the preparation of multigram quantities of API for toxicology studies.