1050238-10-2Relevant academic research and scientific papers
Addressing mechanistic issues in the coupling of isonitriles and carboxylic acids: Potential routes to peptidic constructs
Li, Xuechen,Yuan, Yu,Kan, Cindy,Danishefsky, Samuel J.
supporting information; scheme or table, p. 13225 - 13227 (2009/02/06)
Mechanistic issues surrounding the two component coupling (2CC) reaction of carboxylic acids with isonitriles have been investigated. Experimental details suggest the formimidate carboxylate mixed anhydride intermediate exists in both interdictable and noninterdictable form. Furthermore, the 2CC reaction has been applied to the synthesis of a tripeptide featuring two formyl functional groups. Copyright
On the two-component microwave-mediated reaction of isonitriles with carboxylic acids: Regarding alleged formimidate carboxylate mixed anhydrides
Li, Xuechen,Yuan, Yu,Berkowitz, William F.,Todaro, Louis J.,Danishefsky, Samuel J.
supporting information; experimental part, p. 13222 - 13224 (2009/02/06)
Microwave induced two-component coupling (2CC) reaction of carboxylic acids with isonitriles gives rise to various N-formylamides. The formimidate carboxylate mixed anhydride (FCMA) is proposed as the reactive intermediate, which undergoes 1,3-O→N acyl tr
