10504-13-9Relevant academic research and scientific papers
AMINOACYLINDAZOLE IMMUNOMODULATORS FOR TREATMENT OF AUTOIMMUNE DISEASES
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Paragraph 304, (2017/12/29)
2-Acylindazole compounds of formula I or formula II are disclosed. These compounds inhibit Coagulation Factor XIIa. They are useful to treat autoimmune diseases.
The synthesis of α-azidoesters and geminal triazides
Klahn, Philipp,Erhardt, Hellmuth,Kotthaus, Andreas,Kirsch, Stefan F.
supporting information, p. 7913 - 7917 (2014/08/05)
Three simple methods for the synthesis of geminal triazides are described: Starting from 1) 3-oxocarboxylic acids, 2) iodomethyl ketones, or 3) terminal olefins, a range of triazidomethyl ketones can be constructed under mild oxidative reaction conditions by the use of IBX-SO3K, a sulfonylated derivative of 2-iodoxybenzoic acid (IBX), and NaN3 as an azide source. This is the first report of representatives of this novel class of triazide compounds: Despite their high nitrogen content, the geminal triazides are easy to handle, even when preparative-scale syntheses are performed. (Caution: These procedures still require protective measures!) The triazides are now broadly available for further studies regarding their properties and reactivity. Furthermore, we show how the method can be used to provide α-azidoesters, which are potential building blocks for amino acids. Either/or: Geminal triazides are rapidly constructed with broad scope by the use of oxocarboxylic acids, iodomethyl ketones, or terminal olefins as starting substrates in oxidative azidations with a mild derivative of 2-iodoxybenzoic acid and sodium azide. Along with this little-studied class of organic azides, α-azidoesters were also synthesized.
SYNTHESIS OF THIIRANES FROM EPOXIDES IN THE PRESENCE OF THIOUREA IN A WEAKLY HYDRATED ORGANIC MEDIUM
Bouda, H.,Borredon, M. E.,Delmas, M.,Gaset, A.
, p. 491 - 500 (2007/10/02)
Reactivity of thiourea in the absence or in the presence of ethanol, towards several furanic, aromatic, aliphatic, and cyclic epoxides is studied.These results are compared to other ones obtained in the same conditions with another sulfured agent: KSCN.
