14779-25-0

Basic information

• Product Name: (2E)-3-(5-methyl-2-furyl)acrylic acid
• Synonyms: (2E)-3-(5-methyl-2-furyl)acrylic acid;2-Propenoic acid,3-(5-Methyl-2-furanyl)-
• CAS NO: 14779-25-0
• Molecular Formula: C₈H₈O₃
• Molecular Weight: 152.15
• Mol File: 14779-25-0.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 262.6°C at 760 mmHg
• Flash Point: 112.6°C
• Appearance: /
• Density: 1.225g/cm³
• Vapor Pressure: 0.00546mmHg at 25°C
• Refractive Index: 1.571
• CAS DataBase Reference: (2E)-3-(5-methyl-2-furyl)acrylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2E)-3-(5-methyl-2-furyl)acrylic acid(14779-25-0)
• EPA Substance Registry System: (2E)-3-(5-methyl-2-furyl)acrylic acid(14779-25-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 14779-25-0(Hazardous Substances Data)

Usage

General Description

(2E)-3-(5-methyl-2-furyl)acrylic acid, also known as 2E-3-(5-methyl-2-furanyl)acrylic acid, is an organic compound with the molecular formula C8H8O3. It is a derivative of acrylic acid with a furan ring substitution at the 2-position, which adds a methyl group to the 5-position of the furan ring. (2E)-3-(5-methyl-2-furyl)acrylic acid has a yellowish appearance and is commonly used in the chemical industry for the synthesis of various compounds. It possesses unique properties that make it suitable for use in pharmaceuticals, flavorings, fragrances, and other applications. Additionally, it is used in the manufacturing of polymers and as a starting material for the preparation of other organic compounds. Due to its versatility and diverse applications, (2E)-3-(5-methyl-2-furyl)acrylic acid is an important chemical compound in the field of organic chemistry.

InChI:InChI=1/C8H8O3/c1-6-2-3-7(11-6)4-5-8(9)10/h2-5H,1H3,(H,9,10)/b5-4+

Upstream product

• 620-02-0 5-Methylfurfural 
• 141-82-2 malonic acid 
• 108-24-7 acetic anhydride 

Downstream Products

• 26956-44-5 2-methylfuro<3,2-c>pyridin-4(5H)-one 
• 124-07-2 Octanoic acid 
• 1472655-11-0 C₂₉H₂₇NO₆S 
• 1472655-10-9 C₂₉H₂₇NO₇ 
• 1456-08-2 3-(5'-methyl-2'-furyl)propanoic acid 
• 10504-13-9 2-ethenyl-5-methylfuran 

Relevant articles and documents

Process for the preparation of fatty acids

The invention discloses a method for preparing fatty acid. The method comprises the following steps: providing a first reactant which is a furan compound containing an carbonyl group; providing a second reactant which is a compound containing a carboxyl group, an ester group or an anhydride group and can participate in a condensation reaction with the carbonyl group of the first reactant; allowingthe first reactant and the second reactant to participate in a first condensation reaction, and allowing a C=O bond of the carbonyl group of the first reactant to be connected with alpha carbon of the carbonyl group of the second reactant and to be converted into a C=C bond so as to form a condensation product; and carrying out a second-step reaction under hydrogen pressure in the presence of a co-catalytic system of a hydrogenation catalyst and Lewis acid, opening a furan ring of the condensation product, carrying out hydrodeoxygenation at the same time, removing all oxygen except for oxygenin the carboxyl group, and allowing a carbon chain to be saturated so as to obtain the fatty acid.

Palladium(II)-Catalyzed Oxidative Decarboxylative [2 + 2 + 1] Annulation of Cinnamic Acids with Alkynes: Access to Polysubstituted Pentafulvenes

An unprecedented palladium(II)-catalyzed oxidative decarboxylative [2 + 2 + 1] annulation of cinnamic acids with alkynes has been developed for the synthesis of polysubstituted pentafulvenes. Ag2CO3 and DMSO are essential for the reaction. This protocol features readily available starting materials, a wide substrate scope, and moderate to excellent yields. Moreover, various significant frameworks can be easily obtained from the late-stage transformations of pentafulvenes via oxidation, reduction, and Scholl-type reaction.

A METHOD FOR THE SITE-SPECIFIC ENZYMATIC LABELLING OF NUCLEIC ACIDS IN VITRO BY INCORPORATION OF UNNATURAL NUCLEOTIDES

Provided herein are analogs of unnatural nucleotides bearing predominantly hydrophobic nucleobase analogs that form unnatural base pairs during DNA polymerase- mediated replication of DNA or RNA polymerase-mediated transcription of RNA. In this manner, the unnatural nucleobases can be introduced in a site-specific way into oligonucleotides (single or double stranded DNA or RNA), where they can provide for site-specific cleavage, or can provide a reactive linker than can undergo functionalization with a cargo -bearing reagent by means of reaction with a primary amino group or by means of click chemistry with an alkyne group of the unnatural nucleobase linker.