105052-56-0

Usage

Uses

Used in Pharmaceutical Industry:
L-Phenylalanine, 4-amino-, methyl ester is used as a building block for the synthesis of diaryl urea derivatives, which serve as p38 kinase inhibitors. These inhibitors play a crucial role in regulating cellular processes and have potential therapeutic applications in treating various diseases.
Used in Oncology:
L-Phenylalanine, 4-amino-, methyl ester is used as a key component in the preparation of cytotoxic pentapeptides and their antibody drug conjugates. These conjugates are designed to target and treat cancer cells, providing a more specific and effective approach to cancer therapy.

Upstream product

• 67-56-1 methanol 
• 943-80-6 4-amino-L-phenylalanine 
• 17193-40-7 (S)-4-nitrophenylalanine methyl ester hydrochloride 
• 81677-60-3 (L)-p-Nitrophenylalanine methyl ester 

Downstream Products

• 115082-73-0 H-Phe(4N₃)-OMe 
• 125218-65-7 methyl (S)-2-amino-3-[4-(tert-butoxycarbonylamino)phenyl]propionate 
• 1140067-35-1 methyl (S)-2-amino-3-[4-(9-fluorenylmethoxycarbonylamino)phenyl]propionate 
• 958236-74-3 3-[4-(3-formyl-pyrrol-1-yl)-phenyl]-2-[(1-methyl-cyclohexanecarbonyl)-amino]-propionic acid methyl ester 
• 877374-09-9 2-(2-acetylsulfanylmethyl-3-phenylpropionylamino)-3-(4-aminophenyl)-propionic acid methyl ester 
• 60521-91-7 Ac-Phe(4-NHAc)-OMe 

Relevant academic research and scientific papers

Photohormones Enable Optical Control of the Peroxisome Proliferator-Activated Receptor γ(PPARγ)

Photopharmacology aims at the optical control of protein activity using synthetic photoswitches. This approach has been recently expanded to nuclear hormone receptors with the introduction of "photohormones"for the retinoic acid receptor, farnesoid X rece

COMPOSITIONS CONTAINING, METHODS INVOLVING, AND USES OF NON-NATURAL AMINO ACIDS AND POLYPEPTIDES

Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have at least one aromatic amine group. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one alkylated amine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses.

77. Synthese d'une sonde biotinylee a bras clivable allonge pour l'isolement des recepteurs de l'angiotensine II

We have synthesized a new biotinylated probe for angiotensin II receptors studies; biotinyl-NH(CH2)2-SS-(CH2)2-CO-Gly-εAhx-1,Phe(4N3)8>angiotensin II (5).This molecule can be photoactivated through an arylazido group. 1H-NMR studies suggest that it adopts an extended conformation which should allow a simultaneous recognition of both streptavidin and hormone receptor.It has a good affinity for receptors (Kd= 1 nM) and hence is a promising tool in their detection (autoradiography, gold-, ferritin-, enzyme-, or fluorescent streptavidin derivatives) and separation (cell sorting, affinity chromatography).It can be monoiodinated at its tyrosine residue without a significant loss of affinity.Its extended cleavable arm allows an easy recovery of the probe-receptor'complex from streptavidin.An HPLC monitoring of the synthesis is described, particularly of the segment coupling 1+2 in presence of (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP).This method can be used as well for synthesis of the D-Phe8 derivative that has antagonist properties.