105105-00-8Relevant articles and documents
Convenient synthesis of 7-hydroxyindole
Ishiyama, Kazunao,Yamada, Yasuhiro
, p. 1021 - 1022 (2005)
7-Hydroxyindole, the key building block for the synthesis of AJ-9677 1, was prepared from indoline in six steps in 36% overall yield. AJ-9677 1 is a potent and selective adrenaline β3-agonist being considered as a clinical candidate to treat obesity in those who are suffering from diabetes.
Lactam derivative as well as preparation method and medical application thereof
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Paragraph 0116-0126, (2020/12/30)
The invention relates to lactam derivatives, and a preparation method and medical application thereof. Specifically, the invention relates to lactam derivatives as shown in a general formula (I), a preparation method of the lactam derivatives, pharmaceuti
Design, synthesis, and discovery of 5-piperazinyl-1,2,6,7-tetrahydro-5H-azepino[3,2,1-hi]indol-4-one derivatives: A novel series of mixed dopamine D2/D4 receptor antagonist
Zhao, He,Zhang, Xiaoyan,Hodgetts, Kevin,Thurkauf, Andrew,Hammer, Jack,Chandrasekhar, Jayaraman,Kieltyka, Andrzej,Brodbeck, Robbin,Rachwal, Stanislaw,Primus, Renee,Manly, Charles
, p. 701 - 704 (2007/10/03)
5-Piperazinyl-1,2,6,7-tetrahydro-5H-azepino[3,2,1-hi]indol-4-one derivatives were designed, synthesized, and identified as a new series of mixed dopamine D2/D4 receptor antagonists. This series featured a rigid tricyclic ring system
