10517-64-3

Usage

Uses

Used in Pharmaceutical Industry:
2-(2-Cyanophenyl)acetophenone is used as an intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs with potential therapeutic applications.
Used in Organic Chemistry Research:
In the field of organic chemistry, 2-(2-Cyanophenyl)acetophenone is used as a building block for the creation of complex organic molecules, facilitating the advancement of chemical research and the discovery of novel compounds with specific properties.
Used in Chemical Synthesis:
2-(2-Cyanophenyl)acetophenone is employed as a reagent in chemical synthesis processes, where its aromatic and ketone characteristics are leveraged to produce a range of organic compounds for various applications.

InChI:InChI=1/C15H11NO/c16-11-14-9-5-4-8-13(14)10-15(17)12-6-2-1-3-7-12/h1-9H,10H2

Upstream product

• 93-58-3 benzoic acid methyl ester 
• 529-19-1 2-Methylbenzonitrile 
• 101096-27-9 α,α'-dichloro-bibenzyl-2-carboxylic acid amide 
• 93-89-0 benzoic acid ethyl ester 
• 55086-26-5 o-cyanophenylacetyl chloride 
• 71-43-2 benzene 
• 6919-61-5 N-methoxy-N-methylbenzamide 
• 4505-48-0 2-phenylindene 
• 3759-28-2 (2-cyanophenyl)acetonitrile 
• 98-80-6 phenylboronic acid 
• 100-52-7 benzaldehyde 
• 5079-90-3 (E)-2-styrylbenzoic acid 

Downstream Products

• 37993-73-0 2-<(2-phenyl-1,3-dioxolan-2-yl)methyl>benzonitrile 
• 51787-73-6 4-hydroxy-3-phenylisoquinoline 
• 37993-76-3 3-phenylisoquinoline 
• 105516-75-4 N-methyl-3-phenylisoquinolin-1-amine 
• 105516-73-2 N-(4-chlorophenyl)-3-phenylisoquinolin-1-amine 

Relevant academic research and scientific papers

Me3Al-mediated domino nucleophilic addition/intramolecular cyclisation of 2-(2-oxo-2-phenylethyl)benzonitriles with amines; a convenient approach for the synthesis of substituted 1-aminoisoquinolines

A simple and efficient protocol for the construction of 1-aminoisoquinolines was achieved by treating 2-(2-oxo-2- phenylethyl)benzonitriles with amines in the presence of Me3Al. The reaction proceeds via a domino nucleophilic addition with subsequent intr

C?C bond acylation of oxime ethers via NHC catalysis

An N-heterocyclic carbene (NHC)-catalyzed strategy has been developed to address the issue of using toxic transitional metals in the field of C?C bond activation. The novel reaction mode enables an efficient docking between the cyanoalkyl from the cycloketone oxime derivative and the acyl group from the aldehyde, affording ketonitrile in moderate to good yields, which is one kind of useful building block for synthesizing nitrogen-containing pharmacophores.

Efficient synthesis of isoquinolines in water by a Pd-catalyzed tandem reaction of functionalized alkylnitriles with arylboronic acids

A palladium-catalyzed tandem reaction of 2-(cyanomethyl)benzonitriles or 2-(2-carbonylphenyl)acetonitriles with arylboronic acids in water has been developed for the first time. This reaction features good functional group tolerance and provides a new strategy for the synthesis of diverse isoquinolines under mild conditions. The use of water as the reaction medium makes the synthesis process environmentally benign. Preliminary mechanistic experiments indicate that the major reaction pathway involves carbopalladation of the C(sp3)-cyano group and subsequent intramolecular cyclization findings that were further supported by density functional theory (DFT) calculations.

TEMPO-catalyzed aerobic oxygenation and nitrogenation of olefins via C=C double-bond cleavage

A novel TEMPO-catalyzed aerobic oxygenation and nitrogenation of hydrocarbons via C=C double-bond cleavage has been disclosed. The reaction employs molecular oxygen as the terminal oxidant and oxygen-atom source by metal-free catalysis under mild conditions. This method can be used for the preparation of industrially and pharmaceutically important N- and O-containing motifs, directly from simple and readily available hydrocarbons.

NOVEL DIHYDROPYRIMIDIN-2(1H)-ONE COMPOUNDS AS S-NITROSOGLUTATHIONE REDUCTASE INHIBITORS

The present invention is directed to novel dihydropyrimidin-2(1H)-one compounds useful as S-nitrosoglutathione reductase (GSNOR) inhibitors, pharmaceutical compositions comprising such compounds, and methods of making and using the same.

Biphenylmethyl-substituted pyridones

Biphenylmethyl-substituted pyridones are prepared by reaction of pyridones with appropriate biphenylmethyl compounds. The biphenylmethyl-substituted pyridones can be employed as active compounds in medicaments, in particular for the treatment of arter

An Unexpected Product During Synthesis of 3-Phenylisoquinoline: Improved Preparation of 4-Hydroxy-3-phenylisoquinoline

During repetition of the Bradsher procedure for the preparation of 3-phenylisoquinoline (1), an unexpected by-product was isolated, 4-hydroxy-3-phenylisoquinoline (3).This product is likely formed via allylic oxidation of a 1,4-dihydroisoquinoline interme

Sulfonylbenzyl-substituted benzo- and pyridopyridones

Sulfonylbenzyl-substituted benzo- and pyridopyridones are prepared by reacting corresponding benzo- and pyridopyridones with sulphonylbenzyl compounds. The sulphonylbenzyl-substituted benzo- and pyridopyridones can be employed as active compounds in medicaments, in particular for the treatment of arterial hyper tension and atherosclerosis.