105199-28-8Relevant articles and documents
Reactions of Nitroarenes with Secondary and Tertiary Carbanions Bearing Both a Leaving Group and Electron-Withdrawing Group: An Approach to Dihydronaphth[2,1-c]isoxazole N-oxides and Dihydroisoxazolo[4,3-f]quinoline N-oxides
Maruoka, Hiroshi,Tomioka, Yukihiko
, p. 1051 - 1057 (2007/10/03)
2-Nitronaphthalene (1) and 6-nitroquinoline (2) underwent direct cyclocondensation with secondary and tertiary carbanions derived from a methylene and methine group bearing both a leaving group and electron-withdrawing group (e.g., methyl chloroacetate, ethyl chloroacetate, chloroacetonitrile, methyl 2-chloropropionate, ethyl 2-chloropropionate and 2-chloropropionitrile) in the sodium hydride/N,N-dimethylformamide system at low temperature, giving the corresponding dihydronaphth[2,1-c]isoxazole N-oxides 3 and dihydroisoxazolo[4,3-f]quinoline N-oxides 4. On the other hand, nitroarenes 1 and 2 reacted with secondary carbanions in the sodium hydride/tetrahydrofuran system to yield the corresponding conventional vicarious nucleophilic substitution (VNS) products 5 and 6.
Vicarious Nucleophilic Substitution in Nitroquinolines
Makosza, Mieczyslaw,Kinowski, Andrzej,Danikiewicz, Witold,Mudryk, Boguslaw
, p. 69 - 77 (2007/10/02)
5-Nitro-, 6-nitro-, and 8-nitroquinoline react with the carbanions of chloromethyl phenyl sulfone, chloro-N,N-dimethylmethanesulfonamide and substituted acetonitriles XCH2CN (X=OPh, SPh, Cl) giving products of the vicarious nucleophilic substitution of hy
