105199-48-2

Basic information

• Product Name: (2R,3S,4R)-4-(4-Chloro-phenyl)-5-cyano-2-hydroxy-6-methylsulfanyl-2-phenyl-1,2,3,4-tetrahydro-pyridine-3-carboxylic acid ethyl ester
• CAS NO: 105199-48-2
• Molecular Weight: 428.939
• Mol File: 105199-48-2.mol

Chemical Properties

• CAS DataBase Reference: (2R,3S,4R)-4-(4-Chloro-phenyl)-5-cyano-2-hydroxy-6-methylsulfanyl-2-phenyl-1,2,3,4-tetrahydro-pyridine-3-carboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,3S,4R)-4-(4-Chloro-phenyl)-5-cyano-2-hydroxy-6-methylsulfanyl-2-phenyl-1,2,3,4-tetrahydro-pyridine-3-carboxylic acid ethyl ester(105199-48-2)
• EPA Substance Registry System: (2R,3S,4R)-4-(4-Chloro-phenyl)-5-cyano-2-hydroxy-6-methylsulfanyl-2-phenyl-1,2,3,4-tetrahydro-pyridine-3-carboxylic acid ethyl ester(105199-48-2)

Safety Data

• Hazardous Substances Data: 105199-48-2(Hazardous Substances Data)

Upstream product

• 25354-83-0 (Z)-ethyl 2-benzoyl-3-(4'-chlorophenyl)-3-propenoate 
• 105199-43-7 Sodium; (4R,5S,6R)-4-(4-chloro-phenyl)-3-cyano-5-ethoxycarbonyl-6-hydroxy-6-phenyl-1,4,5,6-tetrahydro-pyridine-2-thiolate 
• 74-88-4 methyl iodide 
• 111564-16-0 C₂₁H₁₈ClN₂O₃S^(1-)*C₅H₁₁N*H⁽¹⁺⁾ 

Downstream Products

• 100784-60-9 ethyl 4-(4-chlorophenyl)-5-cyano-1,6-dihydro-6-oxo-2-phenyl-3-pyridinecarboxylate 
• 105199-68-6 2-Methylthio-4-(p-chlorophenyl)-6-phenyl-5-ethoxycarbonyl-3-cyanopyridine 

Relevant articles and documents

PREPARATION AND PROPERTIES OF PIPERIDINE SALTS OF 6-HYDROXY-4,6-DIARYL-5-ETHOXYCARBONYL-3-CYANOPIPERIDINE-2-THIONES

Alkylation of piperidine salts of 6-hydroxy-4,6-diaryl-5-ethoxycarbonyl-3-cyanopiperidine-2(1H)-thiones yielded 6-hydroxy-2-alkylthio-4,6-diaryl-5-ethoxycarbonyl-3-cyano-3,4,5,6-tetrahydropyridines which were dehydrogenated with the formation of 2-methylthio-1,4- and 4,5-dihydropyridines.The oxidation of the compounds prepared has been studied.

Synthesis of Heterocyclic Compounds, L. - Preparation of Ethyl 2,4-Diaryl-5-cyano-1,6-dihydro-6-thioxo-3-pyridinecarboxylates from Ethyl α-Benzoylcinnamates

Die Umsetzung von α-Benzoylzimtsaeure-ethylestern 2 mit Cyanthioacetamid (1) in Methanol/Natriummethanolat fuehrt zu den Natriumsalzen der 2,4-Diaryl-5-cyan-1,2,3,4-tetrahydro-2-hydroxy-6-mercapto-3-pyridincarbonsaeure-ethylester 3.Diese koennen zu Methylthio-Derivaten 4 methyliert oder zu Dihydropyridonen 5 dehydratisiert werden.Die Verbindungen 4 werden mittels Nitrosylschwefelsaeure zu den entsprechenden aromatischen 2-(Methylthio)pyridinen oxidiert.Andererseits fuehrt eine aehnliche Behandlung der Derivate 5 zwar zu Aromatisierung, aber isoliert werden die Disulfide 6.Reduktion dieser Disulfide ergibt 2-Thiopyridone 7, woraus die zu gehoerigen 2-Pyridone 9 hergestellt werden koennen.Diese Produkte entstehen auch bei der basischen Hydrolyse von (Methylthio)pyridinen 8.