105199-58-4

Basic information

• Product Name: 2.2'-Bis(4-p-chlorophenyl-6-phenyl-5-ethoxycarbonyl-3-cyanopyridyl)-disulfide
• Synonyms: 2.2'-Bis(4-p-chlorophenyl-6-phenyl-5-ethoxycarbonyl-3-cyanopyridyl)-disulfide
• CAS NO: 105199-58-4
• Molecular Weight: 787.747
• Mol File: 105199-58-4.mol

Chemical Properties

• CAS DataBase Reference: 2.2'-Bis(4-p-chlorophenyl-6-phenyl-5-ethoxycarbonyl-3-cyanopyridyl)-disulfide(CAS DataBase Reference)
• NIST Chemistry Reference: 2.2'-Bis(4-p-chlorophenyl-6-phenyl-5-ethoxycarbonyl-3-cyanopyridyl)-disulfide(105199-58-4)
• EPA Substance Registry System: 2.2'-Bis(4-p-chlorophenyl-6-phenyl-5-ethoxycarbonyl-3-cyanopyridyl)-disulfide(105199-58-4)

Safety Data

• Hazardous Substances Data: 105199-58-4(Hazardous Substances Data)

Upstream product

• 25354-83-0 (Z)-ethyl 2-benzoyl-3-(4'-chlorophenyl)-3-propenoate 
• 105199-43-7 Sodium; (4R,5S,6R)-4-(4-chloro-phenyl)-3-cyano-5-ethoxycarbonyl-6-hydroxy-6-phenyl-1,4,5,6-tetrahydro-pyridine-2-thiolate 
• 105199-53-9 6-phenyl-4-(p-chlorophenyl)-5-ethoxycarbonyl-3-cyano-1,4-dihydropyridine-2(3H)-thione 
• 105199-63-1 4-(4-Chloro-phenyl)-5-cyano-2-phenyl-6-thioxo-1,6-dihydro-pyridine-3-carboxylic acid ethyl ester 

Downstream Products

• 105199-63-1 4-(4-Chloro-phenyl)-5-cyano-2-phenyl-6-thioxo-1,6-dihydro-pyridine-3-carboxylic acid ethyl ester 

Relevant articles and documents

Thioxopyridinecarbonitrile as a precursor for thieno-and pyrazolopyridines

PYRIDINETHIONE 1 reacted with alkyl halides or with aliphatic α-?-halocarbonyl to yield the corresponding alkylthio-derivatives 4a-e. which underwent ring closure to form derivatives 5 a.e Pyridinethione 1 reacted with bromomalononitrile, to give the thieno [2,3-b]pyπdine-2.2-dicarbonitrile derivatives 6. Compound 1 reacted with bromomalononitrile to yield structure 7. which was elucidated by the reaction of bromomalononitrile with 8 to furnish compound 9. Treatment of each of 4b and 1113 with hydrazine hydrate, respectively, afforded 3-amIno-4-(4-chlorophenyl)-6-phenyl-lH-pyrazolo [3,4-b] pyrIdIne-5-carboxanilIde (12) and ethyl 3-ammo-4-(4-chlorophenyl)-6-methyl-lH- pyrazoIo[3.4-b] pyrIdIne-5-carboxylate (13), respesctively.

PREPARATION AND PROPERTIES OF PIPERIDINE SALTS OF 6-HYDROXY-4,6-DIARYL-5-ETHOXYCARBONYL-3-CYANOPIPERIDINE-2-THIONES

Alkylation of piperidine salts of 6-hydroxy-4,6-diaryl-5-ethoxycarbonyl-3-cyanopiperidine-2(1H)-thiones yielded 6-hydroxy-2-alkylthio-4,6-diaryl-5-ethoxycarbonyl-3-cyano-3,4,5,6-tetrahydropyridines which were dehydrogenated with the formation of 2-methylthio-1,4- and 4,5-dihydropyridines.The oxidation of the compounds prepared has been studied.

Synthesis of Heterocyclic Compounds, L. - Preparation of Ethyl 2,4-Diaryl-5-cyano-1,6-dihydro-6-thioxo-3-pyridinecarboxylates from Ethyl α-Benzoylcinnamates

Die Umsetzung von α-Benzoylzimtsaeure-ethylestern 2 mit Cyanthioacetamid (1) in Methanol/Natriummethanolat fuehrt zu den Natriumsalzen der 2,4-Diaryl-5-cyan-1,2,3,4-tetrahydro-2-hydroxy-6-mercapto-3-pyridincarbonsaeure-ethylester 3.Diese koennen zu Methylthio-Derivaten 4 methyliert oder zu Dihydropyridonen 5 dehydratisiert werden.Die Verbindungen 4 werden mittels Nitrosylschwefelsaeure zu den entsprechenden aromatischen 2-(Methylthio)pyridinen oxidiert.Andererseits fuehrt eine aehnliche Behandlung der Derivate 5 zwar zu Aromatisierung, aber isoliert werden die Disulfide 6.Reduktion dieser Disulfide ergibt 2-Thiopyridone 7, woraus die zu gehoerigen 2-Pyridone 9 hergestellt werden koennen.Diese Produkte entstehen auch bei der basischen Hydrolyse von (Methylthio)pyridinen 8.