105202-36-6Relevant articles and documents
Aqueous and Visible-Light-Promoted C-H (Hetero)arylation of Uracil Derivatives with Diazoniums
Liu, An-Di,Wang, Zhao-Li,Liu, Li,Cheng, Liang
, p. 16434 - 16447 (2021/11/16)
Direct C5 (hetero)arylation of uracil and uridine substrates with (hetero)aryl diazonium salts under photoredox catalysis with blue light was reported. The coupling proceeds efficiently with diazonium salts and heterocycles in good functional group tolerance at room temperature in aqueous solution without transition-metal components. A plausible radical mechanism has been proposed.
Regioselective direct C-H arylations of protected uracils. Synthesis of 5- and 6-aryluracil bases
Cernova, Miroslava,Cerna, Igor,Pohl, Radek,Hocek, Michal
scheme or table, p. 5309 - 5319 (2011/08/05)
A new regioselective synthesis of 5- and 6-aryluracil bases based on direct C-H arylations of diverse 1,3-protected uracils has been developed. Benzyl-protected uracils were selected as the most practical in terms of stability during the arylation and fac
Effect of bromides on the anomalous photoarylation of 5-halo-1,3-dimethyluracils
Seki, Koh-Ichi,Ohkura, Kazue,Fukai, Yuki,Terashima, Masanao
, p. 341 - 346 (2007/10/02)
Photolysis of 5-chloro- and 5-fluoro-1,3-dimethyluracil in toluene in the presence of a bromide (e.g., p-dibromobenzene, 1,2-dibromoethane, and benzyl bromide) and an acid (trifluoroacetic acid, HBr) afforded 1,3-dimethyl-5-tolyluracils and the 6-isomers as the isomeric mixture. 5-Arylation occurred most favorably at ortho, while meta-isomers were preferential products in 6-arylation. The 5-isomers are suggested to be derived from uracils excited in the singlet states, while the 6-isomers are presumed to result from the uracils excited in the triplet states.