1052138-95-0Relevant academic research and scientific papers
Self-assembly of cationic pyrene nanotubes
Chen, Yulan,Zhu, Bo,Han, Yang,Bo, Zhishan
experimental part, p. 4927 - 4931 (2012/06/29)
The controlled preparation of organic nanotubes via self-assembly of polycyclic aromatics is a contemporary challenge for supramolecular science. Here, we show that the self-assembly of pyrene-containing cationic amphiphiles, 3-(4-(pyren-6-yl)phenoxy)propan-1-ammonium salts (PyPA-Cl, PyPA-Br, and PyPA-SO4), can form high aspect ratio nanotubes with a uniform diameter distribution. We have also demonstrated that the counter anions also play an important role in the self-assembling results. The self-assembly of pyrene-containing cationic amphiphilic molecules with monovalent anions (Cl - and Br-) forms exclusively uniform nanotubes; whereas the self-assembly of amphiphiles with bivalent counter anions (SO 42-) forms exclusively high aspect ratio nanoribbons. Furthermore, we have found that the diameter of the PyPA-Br nanotubes is larger than that of the PyPA-Cl nanotubes. The research results reported herein represent an important step towards the preparation of functional nanostructures with controlled 1D architectures.
Potent inhibitors of LpxC for the treatment of gram-negative infections
Brown, Matthew F.,Reilly, Usa,Abramite, Joseph A.,Arcari, Joel T.,Oliver, Robert,Barham, Rose A.,Che, Ye,Chen, Jinshan Michael,Collantes, Elizabeth M.,Chung, Seung Won,Desbonnet, Charlene,Doty, Jonathan,Doroski, Matthew,Engtrakul, Juntyma J.,Harris, Thomas M.,Huband, Michael,Knafels, John D.,Leach, Karen L.,Liu, Shenping,Marfat, Anthony,Marra, Andrea,McElroy, Eric,Melnick, Michael,Menard, Carol A.,Montgomery, Justin I.,Mullins, Lisa,Noe, Mark. C.,O'Donnell, John,Penzien, Joseph,Plummer, Mark S.,Price, Loren M.,Shanmugasundaram, Veerabahu,Thoma, Christy,Uccello, Daniel P.,Warmus, Joseph S.,Wishka, Donn G.
supporting information; experimental part, p. 914 - 923 (2012/03/27)
In this paper, we present the synthesis and SAR as well as selectivity, pharmacokinetic, and infection model data for representative analogues of a novel series of potent antibacterial LpxC inhibitors represented by hydroxamic acid 1a.
MACROLIDE COMPOUNDS AND METHODS OF MAKING AND USING THE SAME
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Page/Page column 121, (2008/12/07)
The present invention provides amide containing macrocyclic compounds useful as therapeutic agents. More particularly, these compounds are useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents.
