105219-40-7

Basic information

• Product Name: 3,5-Difluoro-benzenepropanaMine
• Synonyms: 3,5-Difluoro-benzenepropanaMine
• CAS NO: 105219-40-7
• Molecular Formula: C₉H₁₁F₂N
• Molecular Weight: 171.1871464
• Mol File: 105219-40-7.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3,5-Difluoro-benzenepropanaMine(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-Difluoro-benzenepropanaMine(105219-40-7)
• EPA Substance Registry System: 3,5-Difluoro-benzenepropanaMine(105219-40-7)

Safety Data

• Hazardous Substances Data: 105219-40-7(Hazardous Substances Data)

Upstream product

• 32085-88-4 3,5-difluorobenzaldehyde 
• 461-96-1 3,5-difluorobromobenzene 

Downstream Products

• 105219-41-8 3-(3,5-difluorophenyl)propyl isothiocyanate 

Relevant articles and documents

8-Hydroxyquinolin-2(1H)-one analogues as potential β2-agonists: Design, synthesis and activity study

β2-Agonists that bind to plasmalemmal β2-adrenoceptors causing cAMP accumulation are widely used as bronchodilators in chronic respiratory diseases. Here, we designed and synthesized a group of 8-hydroxyquinolin-2(1H)-one analogues and studied their β2-agonistic activities with a cellular cAMP assay. Compounds B05 and C08 were identified as potent (EC50 2-agonists among the compounds tested. They behaved as partial β2-agonists in non-overexpressed HEK293 cells, and possessed rapid smooth muscle relaxant actions and long duration of action in isolated guinea pig tracheal strip preparations. In summary, B05 and C08 are β2-agonists with potential applicability in chronic respiratory diseases.

TERTIARY AMIDES AND METHOD OF USE

Compunds of Formula (I) and pharmaceutically acceptable salts thereof, wherein G1, G2, G3, L1, L2, and L3 are as defined in the specification, are useful in treating conditions or disorders prevented by or ameliorated by the modulation of lysophosphatidic acid receptor 1. Methods for making the compounds are described. Also described are pharmaceutical compositions of compounds of formula (I), and methods for using such compounds and compositions.