105264-63-9

Basic information

• Product Name: N-(8-HYDROXYOCTYL)PHTHALIMIDE
• Synonyms: N-(8-HYDROXYOCTYL)PHTHALIMIDE;8-(N-PHTHALIMIDYL)-1-OCTANOL
• CAS NO: 105264-63-9
• Molecular Formula: C₁₆H₂₁NO₃
• Molecular Weight: 275.34
• Product Categories: N-Substituted Maleimides, Succinimides & Phthalimides;N-Substituted Phthalimides
• Mol File: 105264-63-9.mol
• Article Data: 14

Chemical Properties

• Melting Point: 65 °C
• Boiling Point: 426.1±28.0 °C(Predicted)
• Appearance: /
• Density: 1.163±0.06 g/cm3(Predicted)
• PKA: 15.19±0.10(Predicted)
• CAS DataBase Reference: N-(8-HYDROXYOCTYL)PHTHALIMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(8-HYDROXYOCTYL)PHTHALIMIDE(105264-63-9)
• EPA Substance Registry System: N-(8-HYDROXYOCTYL)PHTHALIMIDE(105264-63-9)

Safety Data

• Hazardous Substances Data: 105264-63-9(Hazardous Substances Data)

Upstream product

• 51326-52-4 8-(tetrahydro-2H-pyran-2-yloxy)octan-1-ol 
• 629-41-4 1,8-Octanediol 
• 50816-19-8 8-bromooctanol 
• 136918-14-4 phthalimide 
• 1074-82-4 potassium phtalimide 
• 103010-10-2 8-(p-methylbenzenesulfonyloxy)-1-octanol 
• 23144-52-7 8-chlorooctan-1-ol 
• 148180-09-0 N-<<8-(tetrahydropyran-2-yl)oxy>octyl>phthalimide 

Downstream Products

• 290820-41-6 8'-phthalimidooctyl 2,3,5-tri-O-benzoyl-α-L-arabinofuranoside 
• 1253522-22-3 8-(1,3-dioxoisoindolin-2-yl)octyl 4-methylbenzenesulfonate 
• 1258218-05-1 2-cyano-1-(8-(cyclohexyl(3-morpholinopropyl)amino)octyl)-3-(pyridin-4-yl)guanidine 
• 1258218-08-4 1-(8-(cyclohexyl(3-morpholinopropyl)amino)octyl)-3-(pyridin-3-ylmethyl)urea 
• 1258217-22-9 2-(8-(cyclohexyl(3-morpholinopropyl)amino)octyl)isoindoline-1,3-dione 
• 1258217-25-2 N₁-cyclohexyl-N₁-(3-morpholinopropyl)octane-1,8-diamine 
• 1258217-66-1 2-(8-(benzyloxy(ethyl)amino)octyl)isoindoline-1,3-dione 
• 1258217-67-2 8-(benzyloxy(ethyl)amino)octane-1-amine 
• 19008-71-0 8-aminooctan-1-ol 
• 148180-23-8 8-(phthalimido)octyl 3,4,6-tri-O-benzyl-α-D-mannopyranoside 
• 148180-28-3 8-aminooctyl 2,3,4,6-tetra-O-benzyl-β-D-mannopyranoside 
• 148180-25-0 8-aminooctyl 3,4,6-tri-O-benzyl-α-D-mannopyranoside 
• 290820-44-9 8'-phthalimidooctyl 5-deoxy-5-(E-4-O-(tert-butyldimethylsilyl)-3-methoxycinnamyl)-thio-α-L-arabinofuranoside 
• 290820-50-7 8'-phthalimidooctyl 5-deoxy-5-thio-(E-4-hydroxy-3-methoxycinnamyl)-α-L-arabinofuranoside 

Relevant articles and documents

Modular synthesis, spectroscopic characterization and in situ functionalization using "click" chemistry of azide terminated amide containing self-assembled monolayers

A general and modular synthetic route is developed for the synthesis of azidoalkylthiol molecules, which contain an amide functional group, from common and easily available precursors. SAMs (self-assembled monolayers) formed by these amide containing azidoalkylthiols are characterised by attenuated total reflectance FTIR spectroscopy, X-ray photoelectron spectroscopy, contact angle goniometry and surface enhanced Raman spectroscopy. Signature peaks are identified in the data which allows direct observation of all the functional groups on Au electrodes bearing these monolayers. The terminal azide group is functionalised with electroactive ferrocene group in situ, using "click" chemistry. An alkyne bearing heme derivative is covalently attached using the same technique resulting in O2 reducing electrodes.

IRAK DEGRADERS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

Hydroxypyridinone and 5-Aminolaevulinic Acid Conjugates for Photodynamic Therapy

Photodynamic therapy (PDT) is a promising treatment strategy for malignant and nonmalignant lesions. 5-Aminolaevulinic acid (ALA) is used as a precursor of the photosensitizer, protoporphyrin IX (PpIX), in dermatology and urology. However, the effectiveness of ALA-PDT is limited by the relatively poor bioavailability of ALA and rapid conversion of PpIX to haem. The main goal of this study was to prepare and investigate a library of single conjugates designed to coadminister the bioactive agents ALA and hydroxypyridinone (HPO) iron chelators. A significant increase in intracellular PpIX levels was observed in all cell lines tested when compared to the administration of ALA alone. The higher PpIX levels observed using the conjugates correlated well with the observed phototoxicity following exposure of cells to light. Passive diffusion appears to be the main mechanism for the majority of ALA-HPOs investigated. This study demonstrates that ALA-HPOs significantly enhance phototherapeutic metabolite formation and phototoxicity.