N-(8-HYDROXYOCTYL)PHTHALIMIDE

Base Information

• Chemical Name: N-(8-HYDROXYOCTYL)PHTHALIMIDE
• CAS No.: 105264-63-9
• Molecular Formula: C16H21 N O3
• Molecular Weight: 275.348
• Hs Code.: 2925190090
• Mol file: 105264-63-9.mol

Synonyms:2-(8-Hydroxyoct-1-yl)-1H-isoindol-1,3-(2H)-dione;2-(8-Hydroxyoctyl)-1H-isoindole-1,3(2H)-dione; N-(8-Hydroxyoctyl)phthalimide

Chemical Property of N-(8-HYDROXYOCTYL)PHTHALIMIDE

Chemical Property:

• Melting Point: 65 °C
• Boiling Point: 426.1±28.0 °C(Predicted)
• PKA: 15.19±0.10(Predicted)
• PSA: 57.61000
• Density: 1.163±0.06 g/cm3(Predicted)
• LogP: 2.55340

Purity/Quality:

98%,99%, ^*data from raw suppliers

N-(8-Hydroxyoctyl)phthalimide >98.0%(T) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(8-HYDROXYOCTYL)PHTHALIMIDE

There total 10 articles about N-(8-HYDROXYOCTYL)PHTHALIMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

potassium phtalimide (1074-82-4) + 8-(p-methylbenzenesulfonyloxy)-1-octanol (103010-10-2) → 2-(8-hydroxyoctyl)isoindoline-1,3-dione (105264-63-9)

Guidance literature:

In N,N-dimethyl-formamide; at 100 ℃; for 16h;

Reference yield: 94.0%

8-chlorooctan-1-ol (23144-52-7) + potassium phtalimide (1074-82-4) → 2-(8-hydroxyoctyl)isoindoline-1,3-dione (105264-63-9)

Guidance literature:

In N,N-dimethyl-formamide; Reflux;

DOI:10.1002/ejoc.202100652

Reference yield: 91.0%

8-bromooctanol (50816-19-8) + potassium phtalimide (1074-82-4) → 2-(8-hydroxyoctyl)isoindoline-1,3-dione (105264-63-9)

Guidance literature:

In N,N-dimethyl-formamide; at 90 ℃; for 0.5h;

DOI:10.1016/S0968-0896(00)00037-7

upstream raw materials:

N-<<8-(tetrahydropyran-2-yl)oxy>octyl>phthalimide

8-bromooctanol

potassium phtalimide

8-(tetrahydro-2H-pyran-2-yloxy)octan-1-ol

Downstream raw materials:

8-(1,3-dioxoisoindolin-2-yl)octyl 4-methylbenzenesulfonate

2-cyano-1-(8-(cyclohexyl(3-morpholinopropyl)amino)octyl)-3-(pyridin-4-yl)guanidine

1-(8-(cyclohexyl(3-morpholinopropyl)amino)octyl)-3-(pyridin-3-ylmethyl)urea

2-(8-(cyclohexyl(3-morpholinopropyl)amino)octyl)isoindoline-1,3-dione

Refernces

• 1、 Br?se, Stefan,Koch, Vanessa. "An Intramolecular Iodine-Catalyzed C(sp3)?H Oxidation as a Versatile Tool for the Synthesis of Tetrahydrofurans". supporting information. p. 3478 - 3483. Retrieved 2021/07/22.
• 2、 Guan, Honghao,Sun, Shutao,Mao, Ying,Chen, Lei,Lu, Ran,Huang, Jiancheng,Liu, Lei. "Iron(II)-Catalyzed Site-Selective Functionalization of Unactivated C(sp3)?H Bonds Guided by Alkoxyl Radicals". supporting information. p. 11413 - 11417. Retrieved 2018/08/28.