194497-67-1Relevant academic research and scientific papers
Anion receptor coordination tripods capped by [9]ane-S3
Todd, Adam M.,Swinburne, Adam N.,Goeta, Andres E.,Steed, Jonathan W.
, p. 89 - 96 (2013)
A series of ruthenium(ii) complexes with face-capping [9]ane-S3 ligands are described. The compounds function as supramolecular receptors for anions via three tripodally arranged 3-aminopyridine ligands. The [9]ane-S 3 ligand stabilises the tripodal complexes which are more readily prepared and studied than their π-arene ruthenium(ii) analogues. Pyrenyl derivative 4 displays some activity as a photophysical anion sensor but the anion response is complicated by the complexes concentration dependent emission behaviour. The receptors bind common anions in relatively polar media forming both 1:1 and 1:2 host-anion complexes with the CH...anion interactions involving the thioether ring being implicated in anion binding as well as the convention NH donors.
Ruthenium(II/III)-based compounds with encouraging antiproliferative activity against non-small-cell lung cancer
Nagy, Eszter M.,Pettenuzzo, Andrea,Boscutti, Giulia,Marchiò, Luciano,Dalla Via, Lisa,Fregona, Dolores
, p. 14464 - 14472 (2012)
Hereby we present the synthesis of several ruthenium(II) and ruthenium(III) dithiocarbamato complexes. Proceeding from the Na[trans-RuIII(dmso) 2Cl4] (2) and cis-[RuII(dmso) 4Cl2] (3) precursors, the diamagnetic, mixed-ligand [RuIIL2(dmso)2] complexes 4 and 5, the paramagnetic, neutral [RuIIIL3] monomers 6 and 7, the antiferromagnetically coupled ionic α-[RuIII2L 5]Cl complexes 8 and 9 as well as the β-[RuIII 2L5]Cl dinuclear species 10 and 11 (L=dimethyl- (DMDT) and pyrrolidinedithiocarbamate (PDT)) were obtained. All the compounds were fully characterised by elemental analysis as well as 1H NMR and FTIR spectroscopy. Moreover, for the first time the crystal structures of the dinuclear β-[RuIII2(dmdt)5]BF 4·CHCl3· CH3CN and of the novel [RuIIL2(dmso)2] complexes were also determined and discussed. For both the mono- and dinuclear RuII and Ru III complexes the central metal atoms assume a distorted octahedral geometry. Furthermore, in vitro cytotoxicity of the complexes has been evaluated on non-small-cell lung cancer (NSCLC) NCI-H1975 cells. All the mono- and dinuclear RuIII dithiocarbamato compounds (i.e., complexes 6-10) show interesting cytotoxic activity, up to one order of magnitude higher with respect to cisplatin. Otherwise, no significant antiproliferative effect for either the precursors 2 and 3 or the RuII complexes 4 and 5 has been observed. Copyright
Synthesis, reactivities and anti-cancer properties of ruthenium(II) complexes with a thiaether macrocyclic ligand
O'Riley, Hannah A.,Levina, Aviva,Aitken, Jade B.,Lay, Peter A.
, p. 128 - 138 (2017)
Drug resistance and severe patient side-effects of Pt drugs have spurred research into other metal-based pharmaceuticals and recently Ru complexes have been identified as promising anti-cancer drugs. A series of RuIIcomplexes [RuX2([9]aneS3)(S-dmso)] (X = Cl, Br, I, S-dmso = sulfur-bound dimethylsulfoxide) containing the neutral face-capping sulfur macrocycle ligand, 1,4,7-trithiacyclononane ([9]aneS3) was synthesized, characterized and their substitution reactions and biological activities were investigated. While the iodido complex was not sufficiently soluble for detailed studies, [RuCl2([9]aneS3)(S-dmso)] and [RuBr2([9]aneS3)(S-dmso)] were investigated to determine whether there was a direct relationship between the rates of halido ligand substitution (determined by UV/vis spectroscopy and X-ray absorption spectroscopy) and anti-cancer activities. A two-stage halido substitution process occurred in HEPES buffer (pH 7.4, 310 K). The rate constants for chlorido substitution were a factor of two larger than for the bromido analogue ((4.5 ± 0.2) × 10?4and (1.5 ± 0.1) × 10?4s?1for the chlorido complex and (2.6 ± 0.2) × 10?4and (9.2 ± 0.1) × 10?5s?1for the bromido complex). The corresponding rate constants were a factor of two to three times larger in cell culture media, but the same trends were observed. There was also a third slower reaction in media that had the same rate constant irrespective of the starting complex ((3.6 ± 0.7) × 10?5and (3.9 ± 0.3) × 10?5s?1, respectively). Neither complex exhibited significant cytotoxicity. However, both complexes exhibited anti-invasive properties to highly invasive MDA-MB-231 breast cancer cells. The more reactive chlorido complex was also the most active in the invasion assay when either the cells were treated prior to the addition to collagen matrix, or the top collagen matrix was treated with Ru after adding it to cover the cells and wound.
Photochemistry of trans- and ci5-[RuCl2(dmso)4] in aqueous and nonaqueous solutions
Brindell, Malgorzata,Stochel, Grazyna,Bertolasi, Valerio,Boaretto, Rita,Sostero, Silvana
, p. 2353 - 2359 (2007)
The photochemical behavior of the trans- and cis-[RuCl2(dmso) 4] complexes has been investigated in organic coordinating solvents (dmso, CH3CN) and aqueous solutions by means of electronic and 1H NMR spectroscopy as well as chloride-selective electrode measurements. Excitation in the UVA and visible region of the cis-[RuCl 2(dmso)4] complex in dmso leads to geometric isomerization with quantum yields Φ313 = 0.41 and Φ365 = 0.49 to give the photostable trans complex, whereas in acetonitrile and aqueous solutions, both isomerization and substitution processes occur. Moreover, in the latter two solvents, the trans isomer is photoactive and undergoes substitution reactions. In acetonitrile, for both trans- and cis-[RuCl2(dmso) 4] isomers, selective photolabilization of the dimefhylsulfoxide Ugands results in the formation of the frans-[RuCl2(CH 3CN)4] complex. In aqueous solutions, the dmso and CI - ligands are gradually substituted by water molecules to give as a final product a mixture of (aqua)ruthenium(II) and (aqua)(chlorido)ruthenium(II) complexes. These species may prove to be useful in the binding of cellular components. Wiley-VCH Verlag GmbH & Co. KGaA, 2007.
Synthesis and Characterization of an Epidermal Growth Factor Receptor-Selective RuII Polypyridyl–Nanobody Conjugate as a Photosensitizer for Photodynamic Therapy
Karges, Johannes,Jakubaszek, Marta,Mari, Cristina,Zarschler, Kristof,Goud, Bruno,Stephan, Holger,Gasser, Gilles
, p. 531 - 542 (2020)
There is a current surge of interest in the development of novel photosensitizers (PSs) for photodynamic therapy (PDT), as those currently approved are not completely ideal. Among the tested compounds, we have previously investigated the use of RuII
An efficient route to asymmetrically diconjugated tris(heteroleptic) complexes of Ru(ii)
Burke, Christopher S.,Keyes, Tia E.
, p. 40869 - 40877 (2016)
A highly efficient and versatile route to the preparation of tris(heteroleptic) Ru(ii) polypyridyl complexes is described which permits access to two or more independently conjugatable termini in the final structure. The strategy utilizes the well-known R
Inhibition of human prion neuropeptide PrP106-126 aggregation by hexacoordinated ruthenium complexes
Wang, Xuesong,Zhang, Bingbing,Zhao, Cong,Wang, Yanli,He, Lei,Cui, Menghan,Zhu, Xiaotong,Du, Weihong
, p. 1 - 10 (2013)
Prion disease is a neurodegenerative disorder that can occur among humans and other animals. The aberrant isoform of prion protein PrPSc has been identified as the infectious agent. The neuropeptide PrP106-126 has been widely used as a suitable model to study the biological and physiochemical properties of PrPSc. PrP106-126 shares several physicochemical and biological properties with PrPSc, including cellular toxicity, fibrillogenesis, and membrane-binding affinity. Ruthenium complexes are commonly employed in anti-cancer studies due to their low cellular toxicity. In this study, six hexacoordinated ruthenium complexes with different molecular configurations were used to investigate their effects on PrP106-126 aggregation inhibition. Results revealed that the interaction between the complexes and the peptide included metal coordination and hydrophobic interaction mainly. Those complexes with aromatic structure displayed better inhibitory effects, although they only had a common binding affinity to PrP106-126. This study provided better understanding on the interaction of metal complexes with PrP106-126 and paved the way for potential Ru-based metallodrugs against prion diseases.
Preparation method of ruthenium tetra(dimethyl sulfoxide) dichloride metalloorganic compound
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Paragraph 0014-0016, (2020/12/31)
The molecular formula of a ruthenium tetra(dimethyl sulfoxide) dichloride metalloorganic compound is RuCl2 (DMSO)4, and the preparation method comprises the following steps: adding dimethyl sulfoxideinto a ruthenium reagent, reacting for 12-48 hours at the temperature of 80-90 DEG C until yellow precipitate appears, filtering to obtain a yellow solid, washing the yellow solid with acetone and diethyl ether respectively, and airing in air to obtain the ruthenium tetra(dimethyl sulfoxide) dichloride metalloorganic compound RuCl2 (DMSO)4 containing the dimethyl sulfoxide ligand. Many ruthenium metal complexes with novel structures and special functional properties can be prepared through the ruthenium tetra(dimethyl sulfoxide) dichloride metalloorganic compound, and more possibilities are provided for design and construction of functional complexes. Good potential application is realized in the aspects of molecular-based magnetic materials, nonlinear optical materials, selective catalysis, molecular recognition, gas adsorption, photoelectric materials and the like.
Tris-heteroleptic ruthenium(II) polypyridyl complexes: Synthesis, structural characterization, photophysical, electrochemistry and biological properties
Bhat, Satish S.,Dixit, Ruchi,Grampp, Günter,Hey-Hawkins, Evamarie,Khan, Ayesha,Kumbhar, Avinash S.,L?nnecke, Peter,Purandare, Neeraja,Vanka, Kumar
, (2019/11/05)
Three water-soluble tris-heteroleptic ruthenium(II) polypyridyl complexes [Ru(bpy)(phen)(bpg)]2+ (1), [Ru(bpy)(dppz)(bpg)]2+ (2), and [Ru(phen)(dppz)(bpg)]2+ (3) (where bpy = 2,2′-bipyridine, phen = 1,10-phenanthroline, dppz = dipyrido[3,2-a:2′,3′-c] phenazine, bpg = 4b,5,7,7a-tetrahydro-4b,7a-epiminomethanoimino-6H-imidazo[4,5-f] [1,10] phenanthroline-6,13-dione) have been synthesized and characterized. Molecular structures of complexes 1 and 3 are confirmed by single crystal X-ray structure determination. Interaction of complexes 1–3 with DNA is explored by various spectroscopic techniques. The complexes 1–3 show solvent dependent photophysical properties. Complexes 2 and 3 show extensive “molecular light switch” effect for DNA. The complexes 1–3 are low toxic towards HeLa (human cervical cancer) and HL-60 (human promyelocytic leukemia) cell lines. Further, the cellular uptake of complexes 2 and 3 by cells shows that complexes mainly localised on the nucleus of the cells.
Nitro reduction-based fluorescent probes for carbon monoxide require reactivity involving a ruthenium carbonyl moiety
Yuan, Zhengnan,Yang, Xiaoxiao,De La Cruz, Ladie Kimberly,Wang, Binghe
supporting information, p. 2190 - 2193 (2020/02/27)
Recently, several arylnitro-based fluorescent CO probes have been reported. The design was based on CO's ability to reduce an arylnitro group for fluorescence turn-on. In this work, we assessed the response of three published arylnitro-based fluorescent C
