105355-33-7

Usage

Uses

Used in Pharmaceutical Industry:
5-(4-(2-(3-Methylpyridin-2-yl)ethoxy)benzyl)thiazolidine-2,4-dione is used as a key intermediate in the synthesis of antidiabetic agents for the treatment of diabetes. It plays a crucial role in the development of medications such as Pioglitazone (P471000), which helps in managing blood sugar levels and improving insulin sensitivity in patients with type 2 diabetes.

Upstream product

• 4723-26-6 2-(2-hydroxyethyl)-3-methylpyridine 
• 85583-41-1 4-[2-(3-methyl-2-pyridyl)ethoxy]aniline 
• 350-46-9 4-Fluoronitrobenzene 
• 105355-28-0 Methyl 2-bromo-3-<4-<2-(3-methyl-2-pyridyl)ethoxy>phenyl>propionate 

Relevant academic research and scientific papers

Pyridine N-oxide compounds which are useful as hypoglycemic and hypolipidemic agents

There is disclosed a novel thiazolidinedione derivative of the general formula (I): STR1 wherein R1 and R2 are the same or different and are a hydrogen atom or a lower alkyl group, or a salt thereof. The thiazolidinedione derivative has hypoglycemic activity and hypolipidemic activity.

Studies on antidiabetic agents. Synthesis and hypoglycemic activity of 5-[4-(pyridylalkoxy)benzyl]-2,4-thiazolidinediones

The synthesis of a series of 5-[4-(pyridylalkoxy)benzyl]-2,4-thiazolidinediones is described. These compounds were evaluated for hypoglycemic and hypolipidemic activities in genetically obese and diabetic mice, yellow KK. 2-(2-Pyridyl)alkoxy derivatives were found to have much better hypoglycemic and hypolipidemic activities than 2-(3-pyridyl)- and 2-(4-pyridyl)alkoxy derivatives or even the previously reported compound, ciglitazone. The introduction of a hydroxyl group at the 2-position of the ethoxy chain potentiated the activities. Among the potent compounds, pioglitazone (AD-4833) was selected as a candidate compound.