85583-41-1

Upstream product

• 4723-26-6 2-(2-hydroxyethyl)-3-methylpyridine 
• 350-46-9 4-Fluoronitrobenzene 
• 85583-55-7 3-Methyl-2-[2-(4-nitro-phenoxy)-ethyl]-pyridine 

Downstream Products

• 105355-28-0 Methyl 2-bromo-3-<4-<2-(3-methyl-2-pyridyl)ethoxy>phenyl>propionate 
• 101946-31-0 methyl 3-{4-[2-acetoxy-2-(3-methyl-pyridin-2-yl)ethoxy]phenyl}2-bromopropionate 
• 101931-04-8 5-<4-<2-Hydroxy-2-(3-methyl-2-pyridyl)ethoxy>benzyl>-2,4-thiazolidinedione 
• 105355-33-7 5-[4-[2-(3-methyl-2-pyridyl)ethoxy]benzyl]-2,4-thiazolidinedione 
• 105355-31-5 2-Imino-5-{4-[2-(3-methyl-pyridin-2-yl)-ethoxy]-benzyl}-thiazolidin-4-one 

Relevant academic research and scientific papers

Studies on antidiabetic agents. Synthesis and hypoglycemic activity of 5-[4-(pyridylalkoxy)benzyl]-2,4-thiazolidinediones

The synthesis of a series of 5-[4-(pyridylalkoxy)benzyl]-2,4-thiazolidinediones is described. These compounds were evaluated for hypoglycemic and hypolipidemic activities in genetically obese and diabetic mice, yellow KK. 2-(2-Pyridyl)alkoxy derivatives were found to have much better hypoglycemic and hypolipidemic activities than 2-(3-pyridyl)- and 2-(4-pyridyl)alkoxy derivatives or even the previously reported compound, ciglitazone. The introduction of a hydroxyl group at the 2-position of the ethoxy chain potentiated the activities. Among the potent compounds, pioglitazone (AD-4833) was selected as a candidate compound.

Herbicidal pyridyl-ethoxy-phenyl urea derivatives

Urea derivatives of the general formula: STR1 wherein R1 stands for a lower alkly group; and R2 stands for a lower alkyl group or a lower alkoxy group, or a salt thereof, are novel and have a strong herbicidal activity against various species of weeds and shows a very low phytotoxicity to crop plants.