105357-89-9

Upstream product

• 83-24-9 2,5-dimethyl-1-phenyl-1H-pyrrole 
• 127-19-5 N,N-dimethyl acetamide 
• 38352-74-8 3-acetylhex-5-yn-2-one 
• 62-53-3 aniline 
• 26567-78-2 (Z)-4-(phenylamino)-3-penten-2-one 
• 123-54-6 acetylacetone 
• 3508-78-9 3-allyl-2,4-pentanedione 

Downstream Products

• 1260237-23-7 anilino(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)acetonitrile 

Relevant academic research and scientific papers

Efficient synthesis of substituted pyrroles through iron-mediated oxidation reaction of 3-methylenehexane-2,5-dione with primary amines

An efficient route has been developed for the synthesis of multiple substituted pyrrole derivatives from the readily available agents through iron-mediated oxidative aromatization process in good to excellent yields. This method is well tolerated with a diverse broad range of substrates and a complementary approach to currently available synthetic methods.

Efficient synthesis of highly substituted pyrroles through a Pd(OCOCF 3)2-catalyzed cascade reaction of 2-alkenal-1,3-dicarbonyl compounds with primary amines

We describe an unprecedented Pd(OCOCF3)2-catalyzed cascade process for the synthesis of highly functionalized 1,2,3,5- tetrasubstituted pyrroles with high efficiency. Unlike documented methods relying on preformed enamines and active halogenated terminal alkenes, the process employs simple 2-alkenal-dicarbonyls and primary amines in 'one-pot'. The Royal Society of Chemistry 2013.

Silver-catalysed hydroamination: Synthesis of functionalised pyrroles

It has been shown that functionalised pyrroles can be efficiently prepared using a two-step sequence. This sequence involves the propargylation of secondary enaminones using n-BuLi and propargyl bromide, followed by intramolecular hydroamination catalysed by silver nitrate. The hydroamination can be carried out at room temperature (overnight) or in a domestic microwave oven (60 s).

Synthesis of 1,2,3,5-tetrasubstituted pyrrole derivatives from 2-(2-bromoallyl)-1,3-dicarbonyl compounds

2-(2-Bromoallyl)-1,3-dicarbonyl compounds are converted into β-enamino, β-hydrazino esters and ketones, followed by base-promoted cyclization, leading to the formation of the corresponding 1,2,3,5-tetrasubstituted pyrroles. 1,2,4- and 1,2,3,4-Substituted pyrroles are also isolated as minor products. Starting from the 2-(2-bromoallyl)-cyclohexane-1,3-dione the corresponding tetrahydro indolone is prepared in good yield.

Gold-Catalyzed Sequential Amination/Annulation Reactions of 2-Propynyl-1,3-dicarbonyl Compounds

The gold(III)-catalyzed sequential amination/annulation reaction of 2-propynyl-1,3-dicarbonyl compounds 1 with primary amines 2 produces 1,2,3,5-substituted pyrroles 4 in moderate to high yields.

Photochromic Heterocyclic Fulgides. Part 5. Rearrangement Reactions of (E)-α-1,2,5-Trimethyl-3-pyrrylethylidene(isopropylidene)succinic Anhydride and Related Compounds

The pale yellow (E)-isopropylidene-succinic anhydride 3b undergoes a reversible photochemical reaction to give the deep blue 7,7a-dihydro-1,2,4,7,7,7a-hexamethylindole-5,6-dicarboxylic anhydride 4b which is thermall