1053709-03-7Relevant academic research and scientific papers
Crystal-structure-based design and synthesis of novel C-terminal inhibitors of HIV protease
Varney,Appelt,Kalish,Reddy,Tatlock,Palmer,Romines,Wu,Musick
, p. 2274 - 2284 (2007/10/02)
The X-ray crystal-structure-based design, synthesis, computational evaluation, and activity of a novel class of HIV protease inhibitors are described. The initial lead compounds 2 and 3 were designed by modeling replacement groups for the C-terminal Val-V
