105392-20-9

Upstream product

• 1117-37-9 ethyl (E)-3-(dimethylamino)acrylate 
• 86393-34-2 2,4-dichloro-5-fluorobenzoyl chloride 
• 924-99-2 ethyl 3-(dimethylamino)acrylate 
• 86522-89-6 2,4-dichloro-5-fluoro-benzoic acid 

Downstream Products

• 70458-96-7 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid 
• 68077-26-9 7-chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 
• 106648-05-9 2-(2,4-Dichlor-5-fluorbenzoyl)-3-ethylaminoacrylsaeure-ethylester 
• 628314-25-0 ethyl 2-(2,4-dichloro-5-fluorobenzoyl)-3-(phenethylamino)acrylate 

Relevant academic research and scientific papers

Br?nsted acid-catalyzed chlorination of aromatic carboxylic acids

The chlorination of aromatic carboxylic acids with SOCl2 has been effectively performed by reacting with a Br?nsted acid as the catalyst. Based on this discovery, an efficient catalytic method that is cheaper than traditional catalytic methods was developed. 20 substrates were chlorinated offering excellent yields in a short reaction time. And the SOCl2/Br?nsted acid system has been used in a larger scale preparative reaction. A dual activation mechanism was proposed to prove the irreplaceable system of SOCl2/Br?nsted acid.

Chemical synthesis method for norfloxacin

The invention discloses a chemical synthesis method for norfloxacin. The chemical synthesis method comprises the following steps: (1) synthesis of a compound ethyl quinolinate: 3-ethylamino-2-(2,4-dichloro-5-fluorobenzoyl) ethyl acrylate is dissolved in DMF, potassium carbonate is added, the mixture is heated to 50-80 DEG C, reacts and stands overnight, a product is cooled and poured into cold water, produced solids are filtered, solids are washed with a large amount of water, and the product ethyl quinolinate is obtained; (2) synthesis of a compound quinolinic acid: ethyl quinolinate is dissolved in methanol, hydrochloric acid is added in a ratio being 1:1, reflux is performed for 2 h, white solids are precipitated and filtered, a filter product is washed with water and dried in a vacuum oven for 2 h, and the product quinolinic acid is obtained. The design is reasonable, and one novel norfloxacin synthesis method is selected and has good market application value.

Intermediate synthetic method of carbostyril drug

The invention discloses an intermediate synthetic method of a carbostyril drug. The method comprises the following steps: stirring a mixture of 3-dimethylamino ethyl acrylate and triethylamine at room temperature; adding a solution of 2,4-dichloro-5-fluorobenzoyl chloride through a charging funnel; stirring the mixture to react for 3 hours at 80-90 DEG C; filtering to form a mixture; washing a solid with methylbenzene; dissolving the washed solid with water; dropwise adding ethyl acetate to fully dissolve the solution; cooling the solution, and leaving the solution to stand to separate out a white solid; performing centrifugalization; and drying the solid for 2 hours to obtain a white solid. The method disclosed by the invention is reasonable in design, and the novel method of synthesizing 3-ethylamino-2-(2,4-dichloro-5-fluorobenzoyl) ethyl acrylate has a very good market application value.

SUBSTITUTED QUINOLONE CARBOXYLIC ACIDS, THEIR DERIVATIVES, SITE OF ACTION, AND USES THEREOF

Substituted quinolone carboxylic acids and their derivatives are described. These compounds modulate the effect of gamma -aminobutyric acid (GABA) via a novel site on the GABA>AA receptor complex.