105427-89-2

Upstream product

• 105427-88-1 methyl 3-bromo-5-chloro-2,4-dihydroxy-6-methylbenzoate 
• 77-78-1 dimethyl sulfate 
• 58106-55-1 2,4-dihydroxy-3-bromo-6-methyl-benzoic acid methyl ester 

Downstream Products

• 114046-15-0 3-bromo-5-chloro-2,4-dimethoxy-6-methylbenzoic acid 
• 53939-17-6 5-chloro-2,4-dihydroxy-6-methyl-3-(3-methyl-2-butenyl)benzaldehyde 
• 83324-48-5 3-chloro-5-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-4,6-dihydroxy-2-methylbenzaldehyde 
• 157826-55-6 3-chloro-4,6-dimethoxy-2-methyl-5-(3-methyl-2-butenyl)benzyl alcohol 
• 157826-54-5 3-chloro-5-<(E)-3,7-dimethyl-2,6-octadienyl>-4,6-dimethoxy-2-methylbenzyl alcohol 
• 105427-94-9 3-chloro-5-<(E)-3,7-dimethyl-2,6-octadienyl>-4,6-dimethoxy-2-methylbenzaldehyde 
• 81477-09-0 3-chloro-4,6-dimethoxy-2-methyl-5-(3-methyl-2-butenyl)benzaldehyde 
• 114046-14-9 3-chloro-5-<(E)-3,7-dimethyl-2,6-octadienyl>-4-hydroxy-6-methoxy-2-methylbenzaldehyde 
• 105899-52-3 methyl 3-chloro-4,6-dimethoxy-2-methyl-5-<(E,E)-3-methyl-7-(tetrahydro-5,5-dimethyl-4-oxofuran-2-yl)-octa-2,6-dienyl>benzoate 
• 105878-79-3 methyl 3-chloro-5-<(E,E)-7-(2,5-dihydro-5,5-dimethyl-4-pivaloyloxyfuran-2-yl)-3-methylocta-2,6-dienyl>-4,6-dimethoxy-2-methylbenzoate 
• 105427-91-6 methyl 3-chloro-5-<(E)-3,7-dimethyl-2,6-octadienyl>-4,6-dimethoxy-2-methylbenzoate 
• 950-82-3 methyl 3-chloro-4,6-dimethoxy-2-methylbenzoate 

Relevant academic research and scientific papers

A general approach for the synthesis of phenolic natural products. Facile syntheses of grifolin and colletochlorins B and D

A general approach is established for the synthesis of phenolic compounds having terpenoid side chains: (1) protection of the phenolic hydroxyls in the aromatic precursor by ether formation, (2) coupling the aromatic part with a terpenoid bromide, and (3) deprotection to regenerate the hydroxyl groups. This strategy was successfully applied to the synthesis of colletochlorins B and D and grifolin. Some of the colletochlorin derivatives were found to inhibit the cell growth of P388.

A GENERAL HIGHLY EFFICIENT ACCESS TO PRENYLATED PHENOLIC NATURAL PRODUCTS. SYNTHESIS OF COLLETOCHLORINS B AND D

A general approach is reported for the synthesis of phenolic natural products having terpenoid side chains: (1) construction of the requisite bromophenol ethers, (2) coupling the aromatic ring with a terpenoid chain through copper(I) ate complex, and (3)