83324-48-5

Usage

InChI:InChI=1/C18H23ClO3/c1-11(2)6-5-7-12(3)8-9-14-17(21)15(10-20)13(4)16(19)18(14)22/h6,8,10,21-22H,5,7,9H2,1-4H3/b12-8+

Upstream product

• 6138-90-5 trans-geranyl bromide 
• 83324-59-8 3-chloro-4,6-dihydroxy-2-methyl-benzaldehyde 
• 100-97-0 hexamethylenetetramine 
• 83324-67-8 4-chloro-2-geranylorcinol 
• 105427-94-9 3-chloro-5-<(E)-3,7-dimethyl-2,6-octadienyl>-4,6-dimethoxy-2-methylbenzaldehyde 
• 811-51-8 sodium thioethylate 
• 878480-12-7 2-chloro-4-formyl-5-hydroxy-3-methylphenyl acetate 
• 504-15-4 orcinol 
• 105427-88-1 methyl 3-bromo-5-chloro-2,4-dihydroxy-6-methylbenzoate 
• 105427-91-6 methyl 3-chloro-5-<(E)-3,7-dimethyl-2,6-octadienyl>-4,6-dimethoxy-2-methylbenzoate 
• 157826-54-5 3-chloro-5-<(E)-3,7-dimethyl-2,6-octadienyl>-4,6-dimethoxy-2-methylbenzyl alcohol 
• 105427-89-2 methyl 3-bromo-5-chloro-2,4-dimethoxy-6-methylbenzoate 
• 58106-55-1 2,4-dihydroxy-3-bromo-6-methyl-benzoic acid methyl ester 
• 105450-81-5 3-Chloro-5-((E)-3,7-dimethyl-octa-2,6-dienyl)-2-methyl-4,6-bis-(2-trimethylsilanyl-ethoxymethoxy)-benzaldehyde 

Downstream Products

• 105427-94-9 3-chloro-5-<(E)-3,7-dimethyl-2,6-octadienyl>-4,6-dimethoxy-2-methylbenzaldehyde 
• 1374767-45-9 3-chloro-4,6-dihydroxy-5-[(E)-7-methoxy-3,7-dimethyl-2-octenyl]-2-methylbenzaldehyde 

Relevant academic research and scientific papers

African trypanosomiasis: Synthesis & SAR enabling novel drug discovery of ubiquinol mimics for trypanosome alternative oxidase

African trypanosomiasis is a parasitic disease affecting 5000 humans and millions of livestock animals in sub-Saharan Africa every year. Current treatments are limited, difficult to administer and often toxic causing long term injury or death in many pati

DIHYDROOROTIC ACID DEHYDROGENASE INHIBITOR

The present invention provides a novel dihydroorotic acid dehydrogenase inhibitor which is applicable to various diseases. When used as an active ingredient, a compound represented by formula (I): (wherein X represents a halogen atom, R1 represents a hydrogen atom, R2 represents an alkyl group containing 1 to 7 carbon atoms, R3 represents -CHO, and R4 represents -CH2-CH=C(CH3)-R0 (wherein R0 represents an alkyl group containing 1 to 12 carbon atoms which may have a substituent on the terminal carbon and/or on a non-terminal carbon, etc.)), an optical isomer thereof or a pharmaceutically acceptable salt thereof has a high inhibitory effect on dihydroorotic acid dehydrogenase and can be used as an immunosuppressive agent, a therapeutic agent for rheumatism, an anticancer agent, a therapeutic agent for graft rejection, an antiviral agent, an anti-H. pylori agent, a therapeutic agent for diabetes or the like.

COMPOUNDS FOR USE AS INHIBITORS OF ALTERNATIVE OXIDASE OR CYTOCHROME BC1 COMPLEX

The invention provides compounds for use in inhibiting a microbial alternative oxidase (AOX) and/or cytochrome bc1 complex. The invention extends to the use of such inhibitors in agrochemicals and in pharmaceuticals, for treating microbial infe

NOVEL DIHYDROXYBENZENE DERIVATIVES AND ANTIPROTOZOAL AGENT COMPRISING SAME AS ACTIVE INGREDIENT

Novel compounds below are useful for preventing or treating diseases caused by protozoans. At least one of a compound represented by Formula (I) (wherein, X represents a hydrogen atom or a halogen atom; R1 represents a hydrogen atom; R2 represents a hydrogen atom or a C1-7 alkyl group; R3 represents -CHO, -C(=O)R5, -COOR5 (wherein R5 represents a C1-7 alkyl group), -CH2OH or -COOH; and R4 represents a C1-16 alkyl group having one or more substituents on a terminal carbon atom and/or non-terminal carbon atom(s), a C2-16 alkenyl group having one or more substituents on a terminal carbon atom and/or non-terminal carbon atom(s), or a C2-16 alkynyl group having one or more substituents on a terminal carbon atom and/or non-terminal carbon atom(s)), an optical isomer thereof, and a pharmaceutically acceptable salt is used.

A general approach for the synthesis of phenolic natural products. Facile syntheses of grifolin and colletochlorins B and D

A general approach is established for the synthesis of phenolic compounds having terpenoid side chains: (1) protection of the phenolic hydroxyls in the aromatic precursor by ether formation, (2) coupling the aromatic part with a terpenoid bromide, and (3) deprotection to regenerate the hydroxyl groups. This strategy was successfully applied to the synthesis of colletochlorins B and D and grifolin. Some of the colletochlorin derivatives were found to inhibit the cell growth of P388.

A GENERAL HIGHLY EFFICIENT ACCESS TO PRENYLATED PHENOLIC NATURAL PRODUCTS. SYNTHESIS OF COLLETOCHLORINS B AND D

A general approach is reported for the synthesis of phenolic natural products having terpenoid side chains: (1) construction of the requisite bromophenol ethers, (2) coupling the aromatic ring with a terpenoid chain through copper(I) ate complex, and (3)

A MILD PROCEDURE FOR HYDROLYSIS OF ALKOXYMETHYL ARYL ETHERS TO GIVE HYDROXYARENES. A RATIONAL SYNTHESIS OF ASCOFURANONE

A mild procedure is reported for cleavage of alkoxymethyl aryl ethers with P2I4 to afford hydroxyarenes, and this deprotection method was successfully applied to the synthesis of an antibiotic ascofuranone through a rational approach.

SYNTHESIS OF (+/-)-ASCOCHLORIN, (+/-)-ASCOFURANONE AND LL-Z1272α

Three antibiotics with a common structural feature as prenylated phenols were synthesized: (+/-)-ascochlorin (5-chloro-2,4-dihydroxy-6-methyl-3-benzaldehyde), (+/-)-ascofurano

A GENERAL SYNTHETIC METHOD FOR PRENYLATED PHENOLS OF MICROBIAL ORIGIN

Prenylated phenols with a fully substituted benzene ring, such as colletochlorins A and B, were synthesized by first prenylating 1,5-dimethoxy-3-methyl-1,4-cyclohexadiene and then effecting the aromatization of the prenylated product.