105469-66-7Relevant articles and documents
Synthetic and NMR-Spectroscopic Investigation of Benzylamine Addition to N-Maleylamino Acid Derivatives
Griehl, Carola,Stroehl, Dieter,Jeschkeit, Hans,Kleinpeter, Erich
, p. 647 - 654 (1992)
During the addition of amines to maleylamino acids in general β-amino derivatives are formed.In order to change the reactivity within the vinylogous maleyl system we introduced the β-benzylester group into the starting compound N-(cis-β-carboxyacryloyl)-phenylalanine methylester 1.The obtained benzylester 2 is adding benzylamine in α-position yielding N-benzyl-α-aspartyl(β-benzyl)-phenylalanine methylester 4.The addition reaction was investigated by 1H-NMR-spectroscopy.The structures of the compounds have been confirmed by elemental analysis, IR, 1H-NMR and 13C-NMR spectroscopy.Keywords. α-Aspartyl peptides; N-Maleylamino acid derivatives; Nucleophilic addition.