10547-71-4

Basic information

• Product Name: 1-benzylamino-1-phenyl-propan-2-ol
• Synonyms: 1-benzylamino-1-phenyl-propan-2-ol
• CAS NO: 10547-71-4
• Molecular Weight: 241.333
• Mol File: 10547-71-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-benzylamino-1-phenyl-propan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzylamino-1-phenyl-propan-2-ol(10547-71-4)
• EPA Substance Registry System: 1-benzylamino-1-phenyl-propan-2-ol(10547-71-4)

Safety Data

• Hazardous Substances Data: 10547-71-4(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 26251-08-1 2-nitro-1-phenylpropan-1-ol 
• 705-60-2 (2-nitroprop-1-enyl)benzene 
• 22596-45-8 trans-2-methyl-2-nitro-3-phenyloxirane 

Relevant articles and documents

Dynamic kinetic asymmetric ring-opening/reductive amination sequence of racemic nitroepoxides with chiral amines: Enantioselective synthesis of chiral vicinal diamines

We report a highly diastereoselective synthesis of vicinal diamines by the treatment of nitroepoxides with primary amines and then a reducing agent. When using a chiral primary amine, racemic nitroepoxides are transformed into chiral diamines as a single enantiomers (>95:5 er) through a dynamic kinetic asymmetric transformation (DYKAT). The overall process is a one-pot procedure combining the exposure of nitroepoxides to chiral amines to afford diastereomeric mixtures of aminoimines and subsequent stereoselective imine reduction.