105486-72-4

Basic information

• Product Name: Ethyl 5-bromo-1-methyl-1H-pyrazole-4-carboxylate
• Synonyms: Ethyl 5-bromo-1-methyl-1H-pyrazole-4-carboxylate;5-Bromo-1-methyl-1H-pyrazole-4-carboxylic acid ethyl ester
• CAS NO: 105486-72-4
• Molecular Formula: C₇H₉BrN₂O₂
• Molecular Weight: 233.064
• Mol File: 105486-72-4.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 290.717 °C at 760 mmHg
• Flash Point: 129.621 °C
• Appearance: /
• Density: 1.588 g/cm³
• Vapor Pressure: 0.002mmHg at 25°C
• Refractive Index: 1.578
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -1.13±0.10(Predicted)
• CAS DataBase Reference: Ethyl 5-bromo-1-methyl-1H-pyrazole-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 5-bromo-1-methyl-1H-pyrazole-4-carboxylate(105486-72-4)
• EPA Substance Registry System: Ethyl 5-bromo-1-methyl-1H-pyrazole-4-carboxylate(105486-72-4)

Safety Data

• Hazardous Substances Data: 105486-72-4(Hazardous Substances Data)

Usage

General Description

Ethyl 5-bromo-1-methyl-1H-pyrazole-4-carboxylate is a chemical compound with the molecular formula C7H9BrN2O2. It is a pyrazole derivative with a bromine atom and a methyl group attached to the pyrazole ring, and an ethyl ester group attached to the carboxylic acid moiety. Ethyl 5-bromo-1-methyl-1H-pyrazole-4-carboxylate has potential applications in pharmaceutical and agrochemical industries, as it may exhibit various biological activities and may serve as a building block for the synthesis of more complex molecules. Its precise uses and properties would depend on its specific application and intended function.

InChI:InChI=1/C7H9BrN2O2/c1-3-12-7(11)5-4-9-10(2)6(5)8/h4H,3H2,1-2H3

Upstream product

• 31037-02-2 ethyl 5-amino-1-methyl-1H-pyrazole-4-carboxylate 
• 6994-25-8 3-amino-4-pyrazolecarboxylic acid ethyl ester 
• 1353100-91-0 ethyl 3-bromo-1H-pyrazole-4-carboxylate 
• 74-88-4 methyl iodide 

Downstream Products

• 1415638-13-9 (5-bromo-1-methyl-1H-pyrazol-4-yl)methanol 
• 105994-75-0 1-methyl-5-phenyl-1H-pyrazole-4-carboxylic acid 
• 116344-32-2 ethyl 1-methyl-5-phenyl-1H-pyrazole-4-carboxylate 

Relevant articles and documents

Access and modulation of substituted 1-methyl-1,6-dihydropyrazolo[3,4-c]pyrazoles

Despite the pharmacological potential of the pyrazolo[3,4-c]pyrazoles, only a few methods of preparation and direct functionalization of this moiety have been described. We report herein a convenient design of new pyrazolo[3,4-c]pyrazoles with a high therapeutic impact. The effective chosen strategy consists of hydrazine condensations and C-N Ullmann-type cross-coupling reactions with microwave activation. Moreover, chemoselective bromination of the newly formed bipyrazoles followed by Suzuki-Miyaura cross-coupling reactions allowed the synthesis of a variety of modulated heterobicycles.

CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF

Disclosed herein are small molecule calpain modulator compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to macrocyclic α-keto amide derivatives and their use as therapeutic agents.

PYRANOPYRIDONE INHIBITORS OF TANKYRASE

There are provided compounds of the formula or a pharmaceutically acceptable salt thereof wherein X, M, Y, R1 and R2 are as defined herein. The compounds have activity as anticancer agents.