105486-72-4

Usage

Uses

Used in Pharmaceutical Industry:
Ethyl 5-bromo-1-methyl-1H-pyrazole-4-carboxylate is used as a building block for the synthesis of pharmaceutical compounds, leveraging its unique structure to create new drugs with potential therapeutic applications. Its specific biological activities, once identified, could contribute to the development of treatments for various diseases and conditions.
Used in Agrochemical Industry:
In the agrochemical field, Ethyl 5-bromo-1-methyl-1H-pyrazole-4-carboxylate is utilized as a starting material for the development of new agrochemicals. Its chemical properties may allow it to be incorporated into pesticides, herbicides, or other crop protection products, enhancing their effectiveness and selectivity in agricultural settings.
Given the compound's potential applications, further research and development are necessary to fully understand and harness its capabilities in these industries.

InChI:InChI=1/C7H9BrN2O2/c1-3-12-7(11)5-4-9-10(2)6(5)8/h4H,3H2,1-2H3

Upstream product

• 31037-02-2 ethyl 5-amino-1-methyl-1H-pyrazole-4-carboxylate 
• 6994-25-8 3-amino-4-pyrazolecarboxylic acid ethyl ester 
• 1353100-91-0 ethyl 3-bromo-1H-pyrazole-4-carboxylate 
• 74-88-4 methyl iodide 

Downstream Products

• 1609938-67-1 1-methyl-5-phenoxy-1H-pyrazole-4-carboxylic acid 
• 105994-75-0 1-methyl-5-phenyl-1H-pyrazole-4-carboxylic acid 
• 116344-32-2 ethyl 1-methyl-5-phenyl-1H-pyrazole-4-carboxylate 

Relevant academic research and scientific papers

Access and modulation of substituted 1-methyl-1,6-dihydropyrazolo[3,4-c]pyrazoles

Despite the pharmacological potential of the pyrazolo[3,4-c]pyrazoles, only a few methods of preparation and direct functionalization of this moiety have been described. We report herein a convenient design of new pyrazolo[3,4-c]pyrazoles with a high therapeutic impact. The effective chosen strategy consists of hydrazine condensations and C-N Ullmann-type cross-coupling reactions with microwave activation. Moreover, chemoselective bromination of the newly formed bipyrazoles followed by Suzuki-Miyaura cross-coupling reactions allowed the synthesis of a variety of modulated heterobicycles.

Identification of a Potent, Highly Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor Clinical Candidate

Computational modeling was used to direct the synthesis of analogs of previously reported phosphodiesterase 2A (PDE2A) inhibitor 1 with an imidazotriazine core to yield compounds of significantly enhanced potency. The analog PF-05180999 (30) was subsequen

CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF

Disclosed herein are small molecule calpain modulator compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to macrocyclic α-keto amide derivatives and their use as therapeutic agents.

CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF

Disclosed herein are small molecule calpain modulator compositions, pharmaceutical compositions, the use and preparation thereof.

PYRANOPYRIDONE INHIBITORS OF TANKYRASE

There are provided compounds of the formula or a pharmaceutically acceptable salt thereof wherein X, M, Y, R1 and R2 are as defined herein. The compounds have activity as anticancer agents.

Imidazo[5,1-f][1,2,4]Triazines for the Treatment of Neurological Disorders

The present invention relates to compounds of the Formula and pharmaceutically acceptable salts thereof, to processes for the preparation of, intermediates used in the preparation of, and compositions containing such compounds and the uses of such compounds as a method for the treatment of a disease or condition selected from the group consisting of central nervous system disorders, cognitive disorders, schizophrenia, dementia and other disorders in a mammal.