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Usage

Uses

Used in Organic Synthesis:
1,3-bis(3,4,5-trimethoxyphenyl)urea is used as a synthetic intermediate for the creation of various organic compounds. Its unique structure allows for versatile reactions, making it a valuable component in the synthesis of complex organic molecules.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 1,3-bis(3,4,5-trimethoxyphenyl)urea is used as a building block for the development of new drugs. Its specific molecular features are leveraged to design pharmaceuticals with targeted therapeutic effects.
Used in Pharmaceutical Development:
1,3-bis(3,4,5-trimethoxyphenyl)urea is employed as a potential candidate in the discovery and development of new therapeutic agents. Its biological activity and pharmacological properties are under investigation to determine its efficacy in treating various medical conditions.
Used in Biological Research:
1,3-bis(3,4,5-trimethoxyphenyl)urea is also utilized in biological research to study its interactions with biological systems. Understanding these interactions can provide insights into its potential applications in medicine and other related fields.
Used in Drug Discovery:
1,3-bis(3,4,5-trimethoxyphenyl)urea is used in drug discovery processes to identify new lead compounds. Its unique chemical properties make it a promising candidate for the development of innovative pharmaceuticals.
The specific applications of 1,3-bis(3,4,5-trimethoxyphenyl)urea may vary depending on the research or industrial context, but its versatility in chemical and biological settings highlights its importance in scientific and medical advancements.

Upstream product

• 1016-19-9 3,4,5-trimethoxyphenylisocyanate 
• 124-38-9 carbon dioxide 
• 24313-88-0 3,4,5-Trimethoxyaniline 
• 42543-45-3 3,4,5-trimethoxybenzoyl azide 
• 201230-82-2 carbon monoxide 

Relevant academic research and scientific papers

Hydrosilane-Assisted Synthesis of Urea Derivatives from CO2and Amines

A methodology employing CO2, amines, and phenylsilane was discussed to access aryl- or alkyl-substituted urea derivatives. This procedure was characterized by adopting hydrosilane to promote the formation of ureas directly, without the need to prepare silylamines in advance. Control reactions suggested that FeCl3 was a favorable additive for the generation of ureas, and this 1,5,7-triazabicyclo[4.4.0]dec-5-ene-catalyzed reaction might proceed through nucleophilic addition, silicon migration, and the subsequent formal substitution of silylcarbamate.

Urea-based derivative and synthesis method thereof

The invention discloses a urea-based derivative and a synthesis method thereof. The synthesis method comprises: adding an amine-based catalyst into an amine-based compound used as a raw material, introducing carbon dioxide gas into a reaction bottle, sequentially adding a solvent, hydrosilane and a Lewis acid catalyst into the reaction bottle in the atmosphere of carbon dioxide gas, and carrying out a one-pot reaction to catalytically synthesize the urea-based derivative represented by a formula (I). According to the invention, the preparation method has advantages of mild reaction conditions,simple and easily available raw materials, simple and easily available amine-based catalyst, simple and easily available Lewis acid catalysts, good substrate universality, simple and convenient post-treatment, good yield and the like. The invention further discloses applications of the urea-based derivative represented by the formula (I) in the fields of synthesis and medicinal chemistry.

Pd(OAc)2-catalyzed carbonylation of amines

A phosphine-free catalytic system [Pd(OAc)2-Cu(OAc) 2-air] induced a substrate-specific carbonylation of amines in boiling toluene under CO gas (1 atm). Symmetrical N,N′-dialkylureas were obtained by the carbonylation of primary amines. N,N,N′-Trialkylureas were selectively formed by addition of a secondary amine to the above reaction vessel. Secondary amines did not give tetraalkylureas. However, dialkylamines with a phenyl group on their alkyl chains, such as N-monoalkylated benzylic amine or phenethylamine derivatives, underwent a direct aromatic carbonylation to afford five- or six-membered benzolactams. In the carbonylation, the chelation effect or steric repulsion between Pd(II) and the meta-substituent in the ortho-palladation and the ring sizes of cyclopalladation products that were formed prior to carbonylation were found to generate good site selectivity and increase the reaction rate. In contrast, carbonylation of ω- arylalkylamines with a hydroxyl group gave neither ureas nor benzolactams but instead produced 1,3-oxazolidinones smoothly. Hydrochlorides of amines also underwent carbonylation to afford the corresponding amides under the conditions used. This procedure made it possible to prepare ureas of amino acid esters and N-alkylcarbamates in practical yields.