1055039-22-9Relevant articles and documents
Synthesis and resolution of dinucleotide(TpAZT) phosphoramidates
Lin, Changxue,Fu, Hua,Tu, Guangzhong,Zhao, Yufen
, p. 2553 - 2562 (2007/10/03)
Dinucleotide (TpAZT) phosphoramidates were synthesized through Atherton-Todd reaction of dinucleoside H-phosphonates and amino acid methyl esters, and their diastereomers (Rp and Spu) were separated by crystallization. It was showed that the cheap methyl esters of natural alanine and phenylalanine could act as new chiral auxiliaries for large-scale synthesis of dinucleotide analogs.