637014-44-9

Upstream product

• 30516-87-1 3'-azido-2',3'-deoxythymidine 
• 3868-27-7 triethylammonium 5'-O-dimethoxytritylthymidine 3'-H-phosphonate 
• 160056-33-7 Phenyl 5'-O-dimethoxytritylthymidin-3'-yl phosphonate 
• 40615-39-2 5'-O-(4-4'-dimethoxytrityl)thymidine 

Downstream Products

• 1053633-87-6 C₄₅H₅₁N₈O₁₄P 
• 1055039-22-9 C₄₇H₅₅N₈O₁₄P 
• 1053706-19-6 C₄₈H₅₇N₈O₁₄P 
• 1053647-07-6 C₅₁H₅₅N₈O₁₄P 

Relevant academic research and scientific papers

Synthesis of AZT/d4T boranophosphates as anti-HIV prodrug candidates

AZT/d4T phosphonates were synthesized by sequential condensation of AZT/ d4T with the corresponding alcohols or 5′-DMT-thymidine in the presence of pivaloyl chloride. Sequential silylation, boronation, and hydrolysis in ammonium hydroxide of these phosphonates led to anti-HIV prodrug candidates AZT/d4T boranophosphates.

Synthesis and resolution of dinucleotide(TpAZT) phosphoramidates

Dinucleotide (TpAZT) phosphoramidates were synthesized through Atherton-Todd reaction of dinucleoside H-phosphonates and amino acid methyl esters, and their diastereomers (Rp and Spu) were separated by crystallization. It was showed that the cheap methyl esters of natural alanine and phenylalanine could act as new chiral auxiliaries for large-scale synthesis of dinucleotide analogs.