105516-46-9

Basic information

• Product Name: Pyrrolidine, 1-(2-chlorophenyl)-
• Synonyms: Pyrrolidine, 1-(2-chlorophenyl)-;1-(2-Chlorophenyl)-pyrrolidine
• CAS NO: 105516-46-9
• Molecular Formula: C₁₀H₁₂ClN
• Molecular Weight: 182
• Mol File: 105516-46-9.mol
• Article Data: 16

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Pyrrolidine, 1-(2-chlorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrrolidine, 1-(2-chlorophenyl)-(105516-46-9)
• EPA Substance Registry System: Pyrrolidine, 1-(2-chlorophenyl)-(105516-46-9)

Safety Data

• Hazardous Substances Data: 105516-46-9(Hazardous Substances Data)

Usage

General Description

Pyrrolidine, 1-(2-chlorophenyl)- is a chemical compound with the molecular formula C10H12ClN. It is a derivative of pyrrolidine and contains a 2-chlorophenyl group. Pyrrolidine, 1-(2-chlorophenyl)- is commonly used in the synthesis of pharmaceuticals and agrochemicals. It has also been studied for its potential antiviral and anti-tumor properties. Pyrrolidine, 1-(2-chlorophenyl)- may have applications in the development of new drugs and treatments for various medical conditions. However, like any chemical compound, proper handling and precautions should be taken when working with this substance to ensure safety.

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Relevant articles and documents

Transition-Metal-Free Selective C?H Benzylation of Tertiary Arylamines by a Dearomatization-Aromatization Sequence

Due to the significance of hybrid systems in drug discovery, there is an urgent need to assemble multiple biologically active ingredients into a single molecule. Here, we report a general transition-metal-free selective C?H benzylation of tertiary arylamines in good to excellent yields with a broad substrate scope and high functional-group tolerance under mild conditions. Besides arylamines, some other benzene derivatives also readily furnished the corresponding diaryl methane derivatives with this protocol. A series of control experiments and theoretical calculations indicated that this transition-metal-free reaction is a dearomatization-aromatization process.

Titanium tetrachloride-mediated synthesis of N-aryl-substituted azacycles from cyclic ethers

Titanium tetrachloride-mediated transformation of five- and six-membered cyclic ethers to the corresponding N-aryl-substituted azacycles is conducted in moderate to good yields under mild reaction conditions. Computational studies suggested a mechanism involving a Lewis acid-assisted ring-opening, a seven-membered metallacycle intermediate and a ring-closing process facilitated by direct participation of the metal center.

Organic photoredox catalytic α-C(sp3)-H phosphorylation of saturated: Aza -heterocycles

A metal-free C(sp3)-H phosphorylation of saturated aza-heterocycles via the merger of organic photoredox and Br?nsted acid catalyses was established under mild conditions. This protocol provided straightforward and economic access to a variety of valuable α-phosphoryl cyclic amines by using commercially available diarylphosphine oxide reagents. In addition, the D-A fluorescent molecule DCQ was used for the first time as a photocatalyst and exhibited an excellent photoredox catalytic efficiency in this transformation. A series of mechanistic experiments and DFT calculations demonstrated that this transformation underwent a sequential visible light photoredox catalytic oxidation/nucleophilic addition process.

New N-substituted tetrahydropyrrole derivative synthesis method

The invention provides an amino boron intermediate-mediated synthesis method for preparing N-substituted tetrahydropyrrole derivatives by using aromatic amine and a five-membered oxygen heterocyclic compound as raw materials. According to the present invention, the N-substituted tetrahydropyrrole derivatives are specifically N-aryltetrahydropyrrole and N-aryl 2-methyltetrahydropyrrole, and have the following chemical structure general formulas, wherein Ar is phenyl, 4-methylphenyl, 4-fluorophenyl, 4-chlorophenyl, 2-chlorophenyl, 3-nitrophenyl, 2,4-difluorophenyl, 2,6-dichlorophenyl or 3,5-dichlorophenyl. The present invention discloses the chemical structures and the synthesis method of the compounds.