10552-65-5

Basic information

• Product Name: 4-methyl-N-(tetrahydro-2H-pyran-2-yl)benzenesulfonamide
• Synonyms: 4-methyl-N-(tetrahydro-2H-pyran-2-yl)benzenesulfonamide
• CAS NO: 10552-65-5
• Molecular Weight: 255.338
• Mol File: 10552-65-5.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 4-methyl-N-(tetrahydro-2H-pyran-2-yl)benzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methyl-N-(tetrahydro-2H-pyran-2-yl)benzenesulfonamide(10552-65-5)
• EPA Substance Registry System: 4-methyl-N-(tetrahydro-2H-pyran-2-yl)benzenesulfonamide(10552-65-5)

Safety Data

• Hazardous Substances Data: 10552-65-5(Hazardous Substances Data)

Upstream product

• 110-87-2 3,4-dihydro-2H-pyran 
• 70-55-3 toluene-4-sulfonamide 
• 142-68-7 TETRAHYDROPYRANE 
• 21849-40-1 dibromamine-T 
• 41085-71-6 bromamine T 
• 55962-05-5 [N-(p-tolylsulfonyl)imino]phenyliodinane 
• 127-65-1 chloroamine-T 

Downstream Products

• 16780-44-2 N-(5-hydroxy-pentyl)-4-methyl-benzenesulfonamide 

Relevant articles and documents

α-Amidation of cyclic ethers catalyzed by simple copper salt and a mild and efficient preparation method for α,ω-amino alcohols

Copper(II) trifluoromethanesulfonate catalyzed the amidation of cyclic ethers with iminoiodanes under mild conditions (CH2Cl2, 40°C) with good yields (up to 86% based on 97% conversion) and selectivity (only α-amino products were fou

Iminoiodane- and Br?nsted base-mediated cross dehydrogenative coupling of cyclic ethers with 1,3-dicarbonyl compounds

A one-pot, two-step approach to prepare 2-tetrahydrofuran and -pyran substituted 1,3-dicarbonyl compounds by PhI=NTs-mediated amination/Br?nsted base-catalyzed cross dehydrogenative coupling (CDC) reaction of the cyclic ether and 1,3-dicarbonyl derivative under mild conditions is reported. The reaction is compatible with a variety of cyclic ethers and 1,3-dicarbonyl compounds, affording the corresponding coupled products in moderate to good yields of up to 80% over two steps.

Facile amine formation by intermolecular catalytic amidation of carbon-hydrogen bonds

A simple copper-based catalytic system has been developed for the carbon-hydrogen amidation reaction. The copper-homoscorpionate complex Tp Br3Cu(NCMe) catalyzes the transfer of the nitrene unit NTs (Ts = p-toluenesulfonyl) and its subsequent insertion into the sp3 C-H bonds of alkyl aromatic and cyclic ethers or the sp2 C-H bonds of benzene using PhI=NTs as the nitrene source, affording the corresponding trisubstitued NR1HTs amines in moderate to high yields. The use of the environmentally friendly chloramine-T has also proven effective, with the advantage that sodium chloride is formed as the only byproduct. A tandem, one-pot consecutive nitrene-carbene insertion system has been developed to yield amino acid derivatives.

Copper-Catalyzed Oxidative Acetalization of Boronic Esters: An Umpolung Strategy for Cyclic Acetal Synthesis

A protocol for the acetalization of boronic esters is described. The reaction is catalyzed by copper, and the conditions proved to be mild and were amenable to a variety of functional groups. We expanded the Chan-Lam coupling to include C(sp3) nucleophiles and converted them into corresponding acetals. This method allows for the orthogonal acetalization of substrates with reactive, acid-sensitive functional groups.