105544-62-5Relevant academic research and scientific papers
Studies on synthesis and reactions of some new five and six-membered heterocycles bearing 5,6,7,8-tetrahydrobenzo[b]thieno[2,3-d]pyrimidin-4(3H)-ones skeleton
EL-Mahdy, Ahmed F. M.,Hozien, Zeinab A.,Abdelnaser, Shimaa,Mohammed, Ahmed A. K.,El‐Sawaisi, Suliman M.,El-Sherief, Hassan A. H.
supporting information, p. 3246 - 3260 (2021/06/16)
Thienopyrimidine derivatives are well-known in various pharmaceutical and biomedical domains. In this work, a series of efficacious and novel strategies for the synthesis of thienopyrimidines starting from 2-amino-3-carboethoxy-4,5,6,7-tetrahydrobenzo[b]thiophene has been developed. The regioselectivity of these synthetic strategies was investigated using density functional theory computation and spectroscopic analysis. In addition, the chemical structures of the new thienopyrimidines and their reaction mechanisms, as well as the biological activity of selected compounds were studied.
The Facile Synthesis of 2-Aminothienothiazin-4-ones, in Some Cases 5,6-Anelated
Leistner, Siegfried,Guetschow, Michael,Wagner, Guenther
, p. 466 - 470 (2007/10/02)
The cyclization of ethyl 2-thioureidothiophene-3-carboxylates is known to give 2-thioxothienopyrimidin-4-ones not only under basic conditions but also upon treatment with ethanolic hydrochloric acid.On the other hand, we have found that ethyl 2-thi
