105571-41-3Relevant academic research and scientific papers
Benzenesulfonamide derivatives of 2-substituted 4H-3,1-benzoxazin-4- ones and benzthiazin-4-ones as inhibitors of complement C1r protease
Plummer, Janet S.,Cai, Cuiman,Hays, Sheryl J.,Gilmore, John L.,Emmerling, Mark R.,Michael, Walter,Narasimhan, Lakshmi S.,Watson, M. Desiree,Wang, Kevin,Nath, Rathna,Evans, Lori M.,Jaen, Juan C.
, p. 815 - 820 (1999)
A series of 2-sulfonyl-4H-3,1-benzoxazinones was prepared that inhibit C1r protease in vitro. Several compounds were found to be selective for C1r verses the related serine protease trypsin. Selected compounds demonstrated functional activity in a hemolysis assay.
