Bioorganic and Medicinal Chemistry Letters p. 815 - 820 (1999)
Update date:2022-08-04
Topics:
Plummer, Janet S.
Cai, Cuiman
Hays, Sheryl J.
Gilmore, John L.
Emmerling, Mark R.
Michael, Walter
Narasimhan, Lakshmi S.
Watson, M. Desiree
Wang, Kevin
Nath, Rathna
Evans, Lori M.
Jaen, Juan C.
A series of 2-sulfonyl-4H-3,1-benzoxazinones was prepared that inhibit C1r protease in vitro. Several compounds were found to be selective for C1r verses the related serine protease trypsin. Selected compounds demonstrated functional activity in a hemolysis assay.
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(1986)
