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7-CHLORO-1,2,3,4-TETRAHYDRO-NAPHTHALEN-1-YLAMINE HYDROCHLORIDE is a chloro-substituted tetrahydronaphthalene-based chemical compound featuring an amine group. It is utilized as a building block in the synthesis of new drugs and potential therapeutic agents, with its hydrochloride salt form being favored for improved solubility and stability in aqueous solutions.
Used in Pharmaceutical Research and Development:
7-CHLORO-1,2,3,4-TETRAHYDRO-NAPHTHALEN-1-YLAMINE HYDROCHLORIDE is used as a chemical intermediate for the development of new medications targeting a range of conditions. Its unique structure and properties make it a valuable component in the creation of innovative pharmaceutical compounds.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 7-CHLORO-1,2,3,4-TETRAHYDRO-NAPHTHALEN-1-YLAMINE HYDROCHLORIDE is used as a key constituent in the design and synthesis of novel drug candidates. Its potential applications in the treatment of various diseases are currently under investigation.
Used in Drug Synthesis:
7-CHLORO-1,2,3,4-TETRAHYDRO-NAPHTHALEN-1-YLAMINE HYDROCHLORIDE is used as a precursor in the synthesis of pharmaceuticals, contributing to the development of new therapeutic agents with improved efficacy and safety profiles.
Used in Biochemical Research:
7-CHLORO-1,2,3,4-TETRAHYDRO-NAPHTHALEN-1-YLAMINE HYDROCHLORIDE is also utilized in biochemical research to study its interactions with biological systems, potentially leading to a better understanding of its therapeutic potential and mechanisms of action.

215315-62-1

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215315-62-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 215315-62-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,5,3,1 and 5 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 215315-62:
(8*2)+(7*1)+(6*5)+(5*3)+(4*1)+(3*5)+(2*6)+(1*2)=101
101 % 10 = 1
So 215315-62-1 is a valid CAS Registry Number.

215315-62-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 7-chloro-1,2,3,4-tetrahydronaphthalen-1-amine,hydrochloride

1.2 Other means of identification

Product number -
Other names 7-fluoro-1,2,3,4-tetrahydro-1-naphthylamine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:215315-62-1 SDS

215315-62-1Upstream product

215315-62-1Relevant academic research and scientific papers

ION CHANNEL INHIBITOR COMPOUNDS FOR CANCER TREATMENT

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Paragraph 0261; 0262; 0263; 0268; 0269, (2021/01/25)

The present invention concerns a compound of following general formula (I): where: either R is an R1 group and R′ is an -A1-Cy1 group, or R is an -A1-Cy1 group and R′ is an R1 group, R1 particularly being H or (C1-C6)alkyl group;A1 being an —NH— radical or —NH—CH2— radical;Cy1 particularly being a phenyl group,A is a fused (hetero)aromatic ring having 5 to 7 atoms, for use for treating cancer.

Synthesis and structure-activity relationship studies of 2-(N-substituted)-aminobenzimidazoles as potent negative gating modulators of small conductance Ca2+-activated K+ channels

S?rensen, Ulrik S.,Str?b?k, Dorte,Christophersen, Palle,Hougaard, Charlotte,Jensen, Marianne L.,Nielsen, Elsebet ?.,Peters, Dan,Teuber, Lene

supporting information; scheme or table, p. 7625 - 7634 (2009/12/07)

Small conductance Ca2+-activated K+ channels (SK channels) participate in the control of neuronal excitability, in the shaping of action potential firing patterns, and in the regulation of synaptic transmission. SK channel inhibitors have the potential of becoming new drugs for treatment of various psychiatric and neurological diseases such as depression, cognition impairment, and Parkinson's disease. In the present study we describe the structure-activity relationship (SAR) of a class of 2-(N-substituted)-2- aminobenzimidazoles that constitute a novel class of selective SK channel inhibitors that, in contrast to classical SK inhibitors, do not block the pore of the channel. The pore blocker apamin is not displaced by these compounds in binding studies, and they still inhibit SK channels in which the apamin binding site has been abolished by point mutations. These novel SK inhibitors shift the concentration-response curve for Ca2+ toward higher values and represent the first example of negative gating modulation as a mode-of-action for inhibition of SK channels. The first described compound in this class is NS8593 (14), and the most potent analogue identified in this study is the racemic compound 39 (NS11757), which reversibly inhibits SK3-mediated currents with a Kd value of 9 nM.

NOVEL 2-AMINO BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS MODULATORS OF SMALL-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS

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Page/Page column 24, (2008/06/13)

This invention relates to novel 2-amino benzimidazole derivatives useful as modulators of small-conductance calcium-activated potassium channels (SK channels). In other aspects the invention relates to the use of these compounds in a method for therapy an

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