105598-01-4Relevant academic research and scientific papers
Tandem Alkylation-Reduction of Nitriles. Synthesis of Branched Primary Amines
Weiberth, Franz J.,Hall, Stan S.
, p. 5338 - 5341 (1986)
Tandem alkylation-reduction of a series of nitriles by alkylating with Grignard reagents followed by reducing with lithium-ammonia afforded the corresponding branched primary amines in reasonable isolated yields.Alkyl and aromating nitriles and a variety of Grignard reagents have been employed in this convenient procedure.A mechanism for the reduction of the imine intermediate is suggested.
