Journal of Organic Chemistry p. 5338 - 5341 (1986)
Update date:2022-08-03
Topics:
Weiberth, Franz J.
Hall, Stan S.
Tandem alkylation-reduction of a series of nitriles by alkylating with Grignard reagents followed by reducing with lithium-ammonia afforded the corresponding branched primary amines in reasonable isolated yields.Alkyl and aromating nitriles and a variety of Grignard reagents have been employed in this convenient procedure.A mechanism for the reduction of the imine intermediate is suggested.
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