1056427-10-1

Basic information

• Product Name: 2-Methyl-2-(2-nitrophenyl)propanoyl chloride
• Synonyms: 2-Methyl-2-(2-nitrophenyl)propanoyl chloride
• CAS NO: 1056427-10-1
• Molecular Formula: C₁₀H₁₀ClNO₃
• Molecular Weight: 227.6443
• Mol File: 1056427-10-1.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Methyl-2-(2-nitrophenyl)propanoyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methyl-2-(2-nitrophenyl)propanoyl chloride(1056427-10-1)
• EPA Substance Registry System: 2-Methyl-2-(2-nitrophenyl)propanoyl chloride(1056427-10-1)

Safety Data

• Hazardous Substances Data: 1056427-10-1(Hazardous Substances Data)

Upstream product

• 136764-87-9 2-methyl-2-(2-nitro-phenyl)-propionic acid methyl ester 
• 126802-52-6 2-methyl-2-(2-nitrophenyl)propanoic acid 

Downstream Products

• 154078-34-9 N-(3-quinolyl)-2-methyl-2-(2-nitrophenyl)propanamide 
• 154078-29-2 N-(4-methoxyphenyl)-2-methyl-2-(2-nitrophenyl)propanamide 
• 154078-32-7 N-(4-methoxyphenyl)-N-2-methyl-2-(2-nitrophenyl)propanamide 
• 154078-60-1 2-(2-Amino-phenyl)-N-(4-methoxy-phenyl)-N-methyl-isobutyramide 
• 154078-58-7 2-(2-Amino-phenyl)-N-(4-dimethylamino-phenyl)-isobutyramide 
• 154078-55-4 2-(2-Amino-phenyl)-N-(4-methoxy-phenyl)-isobutyramide 
• 154078-57-6 2-(2-Amino-phenyl)-N-phenyl-isobutyramide 
• 154078-35-0 N-phenyl-2-methyl-2-(2-nitrophenyl)propanamide 
• 154078-36-1 N-<4-(dimethylamino)phenyl>-2-methyl-2-(2-nitrophenyl)propanamide 
• 154078-50-9 N-(2-phenylethyl)-2-methyl-2-(2-nitrophenyl)propanamide 
• 154078-37-2 N-<4-(methylsulfonyl)phenyl>-2-methyl-2-(2-nitrophenyl)propanamide 

Relevant articles and documents

The 2,2-Dimethyl-2-(ortho-nitrophenyl)acetyl (DMNPA) Group: A Novel Protecting Group in Carbohydrate Chemistry

The 2,2-dimethyl-2-(ortho-nitrophenyl)acetyl (DMNPA) group was introduced to synthetic carbohydrate chemistry as a protecting group (PG) for the first time. Benefiting from a unique chemical structure and novel deprotection conditions, the DMNPA group can be cleaved rapidly and mutually orthogonal to other PGs. Orchestrated application of the DMNPA group with other PGs led to the highly efficient synthesis of the glycan of thornasterside A.

N-(2,2-Dimethyl-2-(2-nitrophenyl)acetyl)-4-aminocyclophosphamide as a potential bioreductively activated prodrug of phosphoramide mustard

N-(2,2-Dimethyl-2-(2-nitrophenyl)acetyl)-4-aminocyclophosphamide isomers (DMNA-NH-CPA, 4) were synthesized stereospecifically from Boc-l-Hse(OBn)-OH and the degradation of the corresponding reduced amine 5a was investigated by UV/vis spectroscopy and LC/M